Title |
Successful autologous haematopoietic stem cell transplantation for refractory myasthenia gravis – a case report
|
---|---|
Published in |
Neuromuscular Disorders, September 2016
|
DOI | 10.1016/j.nmd.2016.09.020 |
Pubmed ID | |
Authors |
Irene Håkansson, Anna Sandstedt, Fredrik Lundin, Håkan Askmark, Ritva Pirskanen, Kristina Carlson, Fredrik Piehl, Hans Hägglund |
Abstract |
Myasthenia gravis (MG) is an autoimmune disease, with immune reactivity against the post-synaptic endplate of the neuromuscular junction. Apart from symptomatic treatment with choline esterase blockers, many patients also require immunomodulatory treatment. Despite existing treatment options, some patients are treatment refractory. We describe a patient with severe MG refractory to corticosteroids, four oral immunosuppressants, cyclophosphamide, rituximab and bortezomib who was treated with autologous haematopoietic stem cell transplantation. Two years after this, the patient has significantly improved in objective tests and in quality of life and leads an active life. Diplopia is her only remaining symptom and she is completely free of medication for MG. We believe that autologous haematopoietic stem cell transplantation can be an effective therapeutic option for carefully selected cases of severe, treatment refractory MG. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 23% |
Student > Bachelor | 6 | 17% |
Other | 4 | 11% |
Student > Ph. D. Student | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 5 | 14% |
Unknown | 7 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 43% |
Neuroscience | 5 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 3 | 9% |
Unknown | 7 | 20% |