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Successful autologous haematopoietic stem cell transplantation for refractory myasthenia gravis – a case report

Overview of attention for article published in Neuromuscular Disorders, September 2016
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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35 Mendeley
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Title
Successful autologous haematopoietic stem cell transplantation for refractory myasthenia gravis – a case report
Published in
Neuromuscular Disorders, September 2016
DOI 10.1016/j.nmd.2016.09.020
Pubmed ID
Authors

Irene Håkansson, Anna Sandstedt, Fredrik Lundin, Håkan Askmark, Ritva Pirskanen, Kristina Carlson, Fredrik Piehl, Hans Hägglund

Abstract

Myasthenia gravis (MG) is an autoimmune disease, with immune reactivity against the post-synaptic endplate of the neuromuscular junction. Apart from symptomatic treatment with choline esterase blockers, many patients also require immunomodulatory treatment. Despite existing treatment options, some patients are treatment refractory. We describe a patient with severe MG refractory to corticosteroids, four oral immunosuppressants, cyclophosphamide, rituximab and bortezomib who was treated with autologous haematopoietic stem cell transplantation. Two years after this, the patient has significantly improved in objective tests and in quality of life and leads an active life. Diplopia is her only remaining symptom and she is completely free of medication for MG. We believe that autologous haematopoietic stem cell transplantation can be an effective therapeutic option for carefully selected cases of severe, treatment refractory MG.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 23%
Student > Bachelor 6 17%
Other 4 11%
Student > Ph. D. Student 3 9%
Student > Postgraduate 2 6%
Other 5 14%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 15 43%
Neuroscience 5 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Immunology and Microbiology 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 3 9%
Unknown 7 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2019.
All research outputs
#14,599,900
of 25,373,627 outputs
Outputs from Neuromuscular Disorders
#870
of 1,849 outputs
Outputs of similar age
#173,641
of 330,346 outputs
Outputs of similar age from Neuromuscular Disorders
#16
of 45 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,849 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,346 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.