| Title |
Diabetes and Cognitive Impairment
|
|---|---|
| Published in |
Current Diabetes Reports, August 2016
|
| DOI | 10.1007/s11892-016-0775-x |
| Pubmed ID | |
| Authors |
Lindsay A. Zilliox, Krish Chadrasekaran, Justin Y. Kwan, James W. Russell |
| Abstract |
Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are further exacerbated by the metabolic syndrome. The duration of diabetes and glycemic control may have an impact on the type and severity of cognitive impairment, but as yet we cannot predict who is at greatest risk of developing cognitive impairment. The pathophysiology of cognitive impairment is multifactorial, although dysfunction in each interconnecting pathway ultimately leads to discordance in metabolic signaling. The pathophysiology includes defects in insulin signaling, autonomic function, neuroinflammatory pathways, mitochondrial (Mt) metabolism, the sirtuin-peroxisome proliferator-activated receptor-gamma co-activator 1α (SIRT-PGC-1α) axis, and Tau signaling. Several promising therapies have been identified in pre-clinical studies, but remain to be validated in clinical trials. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Japan | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 442 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Unknown | 441 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 12% |
| Student > Bachelor | 50 | 11% |
| Student > Master | 43 | 10% |
| Researcher | 31 | 7% |
| Student > Postgraduate | 25 | 6% |
| Other | 78 | 18% |
| Unknown | 160 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 82 | 19% |
| Psychology | 33 | 7% |
| Neuroscience | 33 | 7% |
| Biochemistry, Genetics and Molecular Biology | 25 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 4% |
| Other | 76 | 17% |
| Unknown | 176 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2024.
All research outputs
#853,097
of 25,712,965 outputs
Outputs from Current Diabetes Reports
#31
of 1,058 outputs
Outputs of similar age
#16,640
of 383,342 outputs
Outputs of similar age from Current Diabetes Reports
#1
of 21 outputs
Altmetric has tracked 25,712,965 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,058 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 383,342 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.