| Title |
Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target
|
|---|---|
| Published in |
Biochemistry, January 2013
|
| DOI | 10.1134/s0006297913010033 |
| Pubmed ID | |
| Authors |
N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev |
| Abstract |
The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE system, key targets for pharmacological intervention, and interconnection of this system with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote "indirect" antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| India | 1 | 3% |
| Unknown | 35 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Researcher | 7 | 19% |
| Student > Master | 4 | 11% |
| Student > Doctoral Student | 3 | 8% |
| Student > Bachelor | 2 | 5% |
| Other | 6 | 16% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 32% |
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Immunology and Microbiology | 2 | 5% |
| Other | 0 | 0% |
| Unknown | 9 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2013.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Biochemistry
#20,694
of 22,289 outputs
Outputs of similar age
#227,246
of 288,060 outputs
Outputs of similar age from Biochemistry
#64
of 84 outputs
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