Title |
Brain perfusion asymmetry in patients with oral somatic delusions
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Published in |
European Archives of Psychiatry and Clinical Neuroscience, January 2013
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DOI | 10.1007/s00406-013-0390-7 |
Pubmed ID | |
Authors |
Yojiro Umezaki, Ayano Katagiri, Motoko Watanabe, Miho Takenoshita, Tomomi Sakuma, Emi Sako, Yusuke Sato, Akira Toriihara, Akihito Uezato, Hitoshi Shibuya, Toru Nishikawa, Haruhiko Motomura, Akira Toyofuku |
Abstract |
Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. We performed single photon emission computed tomography (SPECT) using (99m)Tc-ethylcysteinate dimer in 16 subjects (cenesthopathy:control = 8:8). The SPECT images were visually assessed qualitatively, and quantitative analyses were also performed using a three-dimensional stereotactic region-of-interest template. The visual assessment revealed a right > left perfusion asymmetry in broad areas of the brain among the patients. The quantitative analysis confirmed that the regional cerebral blood flow values on the right side were significantly larger than those on the left side for most areas of the brain in the patients. A comparison of the R/(R + L) ratios in both groups confirmed the significant brain perfusion asymmetry between the two sides in the callosomarginal, precentral, and temporal regions in the patients. Qualitative evaluation of the SPECT images revealed right > left brain perfusion asymmetry in broad regions of the brain. Moreover, the quantitative analyses confirmed the perfusion asymmetry between the two sides in the frontal and temporal areas. Those may provide the key for elucidation of the pathophysiology of oral cenesthopathy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 20% |
Researcher | 8 | 20% |
Student > Bachelor | 3 | 7% |
Professor > Associate Professor | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 7 | 17% |
Unknown | 10 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 27% |
Psychology | 7 | 17% |
Agricultural and Biological Sciences | 3 | 7% |
Engineering | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 15% |
Unknown | 11 | 27% |