| Title |
Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population
|
|---|---|
| Published in |
Molecular Imaging and Biology, September 2016
|
| DOI | 10.1007/s11307-016-1007-0 |
| Pubmed ID | |
| Authors |
Gina Kavanaugh, Jason Williams, Andrew Scott Morris, Michael L. Nickels, Ronald Walker, Norman Koglin, Andrew W. Stephens, M. Kay Washington, Sunil K. Geevarghese, Qi Liu, Dan Ayers, Yu Shyr, H. Charles Manning |
| Abstract |
Non-invasive imaging is central to hepatocellular carcinoma (HCC) diagnosis; however, conventional modalities are limited by smaller tumors and other chronic diseases that are often present in patients with HCC, such as cirrhosis. This pilot study evaluated the feasibility of (4S)-4-(3-[(18)F]fluoropropyl)-L-glutamic acid ([(18)F]FSPG) positron emission tomography (PET)/X-ray computed tomography (CT) to image HCC. [(18)F]FSPG PET/CT was compared to standard-of-care (SOC) magnetic resonance imaging (MRI) and CT, and [(11)C]acetate PET/CT, commonly used in this setting. We report the largest cohort of HCC patients imaged to date with [(18)F]FSPG PET/CT and present the first comparison to [(11)C]acetate PET/CT and SOC imaging. This study represents the first in a US HCC population, which is distinguished by different underlying comorbidities than non-US populations. xC- transporter RNA and protein levels were evaluated in HCC and matched liver samples from The Cancer Genome Atlas (n = 16) and a tissue microarray (n = 83). Eleven HCC patients who underwent prior MRI or CT scans were imaged by [(18)F]FSPG PET/CT, with seven patients also imaged with [(11)C]acetate PET/CT. xC- transporter RNA and protein levels were elevated in HCC samples compared to background liver. Over 50 % of low-grade HCCs and ~70 % of high-grade tumors exceeded background liver protein expression. [(18)F]FSPG PET/CT demonstrated a detection rate of 75 %. [(18)F]FSPG PET/CT also identified an HCC devoid of typical MRI enhancement pattern. Patients scanned with [(18)F]FSPG and [(11)C]acetate PET/CT exhibited a 90 and 70 % detection rate, respectively. In dually positive tumors, [(18)F]FSPG accumulation consistently resulted in significantly greater tumor-to-liver background ratios compared with [(11)C]acetate PET/CT. [(18)F]FSPG PET/CT is a promising modality for HCC imaging, and larger studies are warranted to examine [(18)F]FSPG PET/CT impact on diagnosis and management of HCC. [(18)F]FSPG PET/CT may also be useful for phenotyping HCC tumor metabolism as part of precision cancer medicine. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
| Unknown | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 20% |
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 4 | 9% |
| Student > Doctoral Student | 2 | 4% |
| Professor | 2 | 4% |
| Other | 7 | 15% |
| Unknown | 14 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 24% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Nursing and Health Professions | 3 | 7% |
| Chemistry | 3 | 7% |
| Neuroscience | 3 | 7% |
| Other | 6 | 13% |
| Unknown | 17 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2017.
All research outputs
#6,714,791
of 25,371,288 outputs
Outputs from Molecular Imaging and Biology
#190
of 837 outputs
Outputs of similar age
#95,468
of 330,815 outputs
Outputs of similar age from Molecular Imaging and Biology
#2
of 15 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 837 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.