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X Demographics
Mendeley readers
Attention Score in Context
| Title |
EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme
|
|---|---|
| Published in |
Cancer Cell, February 2013
|
| DOI | 10.1016/j.ccr.2013.01.007 |
| Pubmed ID | |
| Authors |
Bryan W. Day, Brett W. Stringer, Fares Al-Ejeh, Michael J. Ting, John Wilson, Kathleen S. Ensbey, Paul R. Jamieson, Zara C. Bruce, Yi Chieh Lim, Carolin Offenhäuser, Sara Charmsaz, Leanne T. Cooper, Jennifer K. Ellacott, Angus Harding, Lucie Leveque, Po Inglis, Suzanne Allan, David G. Walker, Martin Lackmann, Geoffrey Osborne, Kum Kum Khanna, Brent A. Reynolds, Jason D. Lickliter, Andrew W. Boyd |
| Abstract |
Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is frequently overexpressed in GBM and, in particular, in the most aggressive mesenchymal subtype. Importantly, EphA3 is highly expressed on the tumor-initiating cell population in glioma and appears critically involved in maintaining tumor cells in a less differentiated state by modulating mitogen-activated protein kinase signaling. EphA3 knockdown or depletion of EphA3-positive tumor cells reduced tumorigenic potential to a degree comparable to treatment with a therapeutic radiolabelled EphA3-specific monoclonal antibody. These results identify EphA3 as a functional, targetable receptor in GBM. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 166 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 25% |
| Researcher | 32 | 19% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 16 | 9% |
| Professor > Associate Professor | 10 | 6% |
| Other | 28 | 16% |
| Unknown | 22 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 36% |
| Biochemistry, Genetics and Molecular Biology | 30 | 18% |
| Medicine and Dentistry | 26 | 15% |
| Chemistry | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 27 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2023.
All research outputs
#418,236
of 25,374,647 outputs
Outputs from Cancer Cell
#273
of 3,149 outputs
Outputs of similar age
#3,053
of 291,217 outputs
Outputs of similar age from Cancer Cell
#1
of 42 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.