| Title |
The Implication of Vitamin D and Autoimmunity: a Comprehensive Review
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, January 2013
|
| DOI | 10.1007/s12016-013-8361-3 |
| Pubmed ID | |
| Authors |
Chen-Yen Yang, Patrick S. C. Leung, Iannis E. Adamopoulos, M. Eric Gershwin |
| Abstract |
Historically, vitamin D has been associated with the regulation of bone metabolism. However, increasing evidence demonstrates a strong association between vitamin D signaling and many biological processes that regulate immune responses. The discovery of the vitamin D receptor in multiple immune cell lineages, such as monocytes, dendritic cells, and activated T cells credits vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases. In this review we, discuss five major areas in vitamin D biology of high immunological significance: (1) the metabolism of vitamin D; (2) the significance of vitamin D receptor polymorphisms in autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; (3) vitamin D receptor transcriptional regulation of immune cell lineages, including Th1, Th17, Th2, regulatory T, and natural killer T cells; (4) the prevalence of vitamin D insufficiency/deficiency in patients with multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; and finally, (5) the therapeutic effects of vitamin D supplementation on disease severity and progression. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 26% |
| United Kingdom | 4 | 13% |
| Indonesia | 2 | 6% |
| Italy | 2 | 6% |
| Canada | 2 | 6% |
| France | 1 | 3% |
| Curaçao | 1 | 3% |
| Argentina | 1 | 3% |
| Unknown | 10 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 77% |
| Practitioners (doctors, other healthcare professionals) | 6 | 19% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 367 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 5 | 1% |
| Germany | 2 | <1% |
| Colombia | 1 | <1% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 354 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 68 | 19% |
| Student > Master | 51 | 14% |
| Student > Ph. D. Student | 35 | 10% |
| Researcher | 31 | 8% |
| Student > Postgraduate | 27 | 7% |
| Other | 67 | 18% |
| Unknown | 88 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 116 | 32% |
| Agricultural and Biological Sciences | 39 | 11% |
| Nursing and Health Professions | 26 | 7% |
| Biochemistry, Genetics and Molecular Biology | 25 | 7% |
| Immunology and Microbiology | 19 | 5% |
| Other | 40 | 11% |
| Unknown | 102 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 118. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2024.
All research outputs
#361,014
of 26,017,215 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#13
of 727 outputs
Outputs of similar age
#2,574
of 296,443 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#1
of 17 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 727 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.