You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB
|
|---|---|
| Published in |
Nature Communications, September 2016
|
| DOI | 10.1038/ncomms12976 |
| Pubmed ID | |
| Authors |
Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper-White, Bruno van Swinderen, Frédéric A. Meunier |
| Abstract |
Axonal retrograde transport of signalling endosomes from the nerve terminal to the soma underpins survival. As each signalling endosome carries a quantal amount of activated receptors, we hypothesized that it is the frequency of endosomes reaching the soma that determines the scale of the trophic signal. Here we show that upregulating synaptic activity markedly increased the flux of plasma membrane-derived retrograde endosomes (labelled using cholera toxin subunit-B: CTB) in hippocampal neurons cultured in microfluidic devices, and live Drosophila larval motor neurons. Electron and super-resolution microscopy analyses revealed that the fast-moving sub-diffraction-limited CTB carriers contained the TrkB neurotrophin receptor, transiently activated by synaptic activity in a BDNF-independent manner. Pharmacological and genetic inhibition of TrkB activation selectively prevented the coupling between synaptic activity and the retrograde flux of signalling endosomes. TrkB activity therefore controls the encoding of synaptic activity experienced by nerve terminals, digitalized as the flux of retrogradely transported signalling endosomes. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 44% |
| Australia | 2 | 22% |
| France | 1 | 11% |
| United Kingdom | 1 | 11% |
| Unknown | 1 | 11% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 2% |
| Unknown | 81 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 29% |
| Researcher | 19 | 23% |
| Student > Doctoral Student | 7 | 8% |
| Student > Master | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 10 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 26 | 31% |
| Agricultural and Biological Sciences | 20 | 24% |
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Medicine and Dentistry | 4 | 5% |
| Physics and Astronomy | 3 | 4% |
| Other | 9 | 11% |
| Unknown | 11 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2017.
All research outputs
#2,130,825
of 22,890,496 outputs
Outputs from Nature Communications
#24,534
of 47,156 outputs
Outputs of similar age
#39,148
of 322,482 outputs
Outputs of similar age from Nature Communications
#473
of 902 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,156 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,482 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 902 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.