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A simple iterative method for the synthesis of β-(1→6)-glucosamine oligosaccharides

Overview of attention for article published in Carbohydrate Research, February 2013
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Title
A simple iterative method for the synthesis of β-(1→6)-glucosamine oligosaccharides
Published in
Carbohydrate Research, February 2013
DOI 10.1016/j.carres.2013.01.008
Pubmed ID
Authors

Lucy G. Weaver, Yogendra Singh, Joanne T. Blanchfield, Paul L. Burn

Abstract

Poly-N-acetylglucosamine (PNAG) saccharides are an important constituent of bacterial biofilms, such as those produced by Staphylococcus aureus. We have developed a simple two-step iterative method for the synthesis of β-(1→6)-glucosamine oligosaccharides that are structurally similar to PNAG. We illustrate the method with the formation of a pentasaccharide. The key building block is an orthogonally protected N-trifluoroacetamido thioglycoside donor that was added in succession to a glycosyl acceptor, enabling efficient glycosylation of the growing chain. In the second step of the iterative cycle, this building block is quantitatively deprotected at the C-6-hydroxyl position, ready for the next saccharide addition. Building from an azido-functionalised GlcNAc monosaccharide acceptor, the pentasaccharide was synthesised in seven steps in an overall yield of 25%.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 8%
Netherlands 1 4%
Denmark 1 4%
Taiwan 1 4%
Unknown 20 80%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 32%
Researcher 5 20%
Professor 2 8%
Other 2 8%
Student > Master 2 8%
Other 1 4%
Unknown 5 20%
Readers by discipline Count As %
Chemistry 11 44%
Biochemistry, Genetics and Molecular Biology 5 20%
Medicine and Dentistry 2 8%
Agricultural and Biological Sciences 1 4%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2013.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Carbohydrate Research
#4,923
of 5,019 outputs
Outputs of similar age
#263,742
of 296,590 outputs
Outputs of similar age from Carbohydrate Research
#15
of 19 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,019 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,590 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.