Title |
Bioproduction of riboflavin: a bright yellow history
|
---|---|
Published in |
Journal of Industrial Microbiology & Biotechnology, May 2017
|
DOI | 10.1007/s10295-016-1842-7 |
Pubmed ID | |
Authors |
José Luis Revuelta, Rodrigo Ledesma-Amaro, Patricia Lozano-Martinez, David Díaz-Fernández, Rubén M Buey, Alberto Jiménez |
Abstract |
Riboflavin (vitamin B2) is an essential nutrient for humans and animals that must be obtained from the diet. To ensure an optimal supply, riboflavin is used on a large scale as additive in the food and feed industries. Here, we describe a historical overview of the industrial process of riboflavin production starting from its discovery and the need to produce the vitamin in bulk at prices that would allow for their use in human and animal nutrition. Riboflavin was produced industrially by chemical synthesis for many decades. At present, the development of economical and eco-efficient fermentation processes, which are mainly based on Bacillus subtilis and Ashbya gossypii strains, has replaced the synthetic process at industrial scale. A detailed account is given of the development of the riboflavin overproducer strains as well as future prospects for its improvement. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | <1% |
Unknown | 145 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 30 | 21% |
Student > Master | 23 | 16% |
Researcher | 20 | 14% |
Student > Ph. D. Student | 17 | 12% |
Other | 6 | 4% |
Other | 12 | 8% |
Unknown | 38 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 45 | 31% |
Agricultural and Biological Sciences | 18 | 12% |
Chemistry | 6 | 4% |
Immunology and Microbiology | 6 | 4% |
Engineering | 5 | 3% |
Other | 25 | 17% |
Unknown | 41 | 28% |