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Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides

Overview of attention for article published in Journal of Natural Products, September 2016
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Title
Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides
Published in
Journal of Natural Products, September 2016
DOI 10.1021/acs.jnatprod.6b00371
Pubmed ID
Authors

Kathrin Wittstein, Monique Rascher, Zeljka Rupcic, Eduard Löwen, Barbara Winter, Reinhard W. Köster, Marc Stadler

Abstract

Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.

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Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Germany 1 1%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 14%
Student > Master 8 11%
Researcher 8 11%
Student > Bachelor 6 8%
Professor 4 6%
Other 8 11%
Unknown 27 38%
Readers by discipline Count As %
Chemistry 12 17%
Agricultural and Biological Sciences 12 17%
Biochemistry, Genetics and Molecular Biology 10 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Unspecified 1 1%
Other 3 4%
Unknown 31 44%