| Title |
Lithium chloride enhances bone regeneration and implant osseointegration in osteoporotic conditions
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, October 2016
|
| DOI | 10.1007/s00774-016-0783-6 |
| Pubmed ID | |
| Authors |
Yifan Jin, Lihua Xu, Xiaohui Hu, Shixian Liao, Janak L. Pathak, Jinsong Liu |
| Abstract |
Osteoporotic patients have a high risk of dental and orthopedic implant failure. Lithium chloride (LiCl) has been reported to enhance bone formation. However, the role of LiCl in the success rate of dental and orthopedic implants in osteoporotic conditions is still unknown. We investigated whether LiCl enhances implant osseointegration, implant fixation, and bone formation in osteoporotic conditions. Sprague-Dawley female rats (n = 18) were ovariectomized (OVX) to induce osteoporosis, and another nine rats underwent sham surgery. Three months after surgery, titanium implants were implanted in the tibia of the OVX and sham group rats. After implantation, the OVX rats were gavaged with 150 mg/kg/2 days of LiCl (OVX + LiCl group) or saline (OVX group), and sham group rats were gavaged with saline for 3 months. Implant osseointegration and bone formation were analyzed using histology, biomechanical testing, and micro computed tomography (micro-CT). More bone loss was observed in the OVX group compared to the control, and LiCl treatment enhanced bone formation and implant fixation in osteoporotic rats. In the OVX group, bone-implant contact (BIC) was decreased by 81.2 % compared to the sham group. Interestingly, the OVX + LiCl group showed 4.4-fold higher BIC compared to the OVX group. Micro-CT data of tibia from the OVX + LiCl group showed higher bone volume, trabecular thickness, trabecular number, and osseointegration compared to the OVX group. Maximum push-out force and implant-bone interface shear strength were 2.9-fold stronger in the OVX + LiCl group compared to the OVX group. In conclusion, LiCl enhanced implant osseointegration, implant fixation, and bone formation in osteoporotic conditions, suggesting LiCl as a promising therapeutic agent to prevent implant failure and bone loss in osteoporotic conditions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 12% |
| Student > Master | 6 | 11% |
| Researcher | 5 | 9% |
| Professor > Associate Professor | 5 | 9% |
| Student > Doctoral Student | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 22 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 35% |
| Chemistry | 3 | 5% |
| Engineering | 3 | 5% |
| Materials Science | 2 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 24 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2016.
All research outputs
#21,180,380
of 23,842,189 outputs
Outputs from Journal of Bone and Mineral Metabolism
#563
of 787 outputs
Outputs of similar age
#279,915
of 322,454 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#7
of 19 outputs
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So far Altmetric has tracked 787 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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