Title |
The anti-cancer effects of quinolone antibiotics?
|
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Published in |
European Journal of Clinical Microbiology & Infectious Diseases, August 2007
|
DOI | 10.1007/s10096-007-0375-4 |
Pubmed ID | |
Authors |
M. Paul, A. Gafter-Gvili, A. Fraser, L. Leibovici |
Abstract |
A previous meta-analysis showed that quinolones administered for prophylaxis of infections among cancer patients reduced all-cause mortality. We extracted from the primary trials infection-related and all-cause mortality as reported and assessed the effect of quinolones on non-infection-related mortality through meta-analysis. Among trials comparing quinolones to placebo or no treatment, a significant reduction in non-infection-related mortality was observed (relative risk 0.54, 95% confidence interval 0.32-0.93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 24% |
Other | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Bachelor | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Other | 5 | 20% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 16% |
Agricultural and Biological Sciences | 4 | 16% |
Chemistry | 4 | 16% |
Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 24% |