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Attention Score in Context
| Title |
Physical exercise induces structural alterations in the hippocampal astrocytes: exploring the role of BDNF-TrkB signaling
|
|---|---|
| Published in |
Brain Structure and Function, September 2016
|
| DOI | 10.1007/s00429-016-1308-8 |
| Pubmed ID | |
| Authors |
Atoossa Fahimi, Mehmet Akif Baktir, Sarah Moghadam, Fatemeh S. Mojabi, Krithika Sumanth, M. Windy McNerney, Ravikumar Ponnusamy, Ahmad Salehi |
| Abstract |
While it has been known that physical activity can improve cognitive function and protect against neurodegeneration, the underlying mechanisms for these protective effects are yet to be fully elucidated. There is a large body of evidence indicating that physical exercise improves neurogenesis and maintenance of neurons. Yet, its possible effects on glial cells remain poorly understood. Here, we tested whether physical exercise in mice alters the expression of trophic factor-related genes and the status of astrocytes in the dentate gyrus of the hippocampus. In addition to a significant increase in Bdnf mRNA and protein levels, we found that 4 weeks of treadmill and running wheel exercise in mice, led to (1) a significant increase in synaptic load in the dentate gyrus, (2) alterations in astrocytic morphology, and (3) orientation of astrocytic projections towards dentate granule cells. Importantly, these changes were possibly linked to increased TrkB receptor levels in astrocytes. Our study suggests that astrocytes actively respond and could indeed mediate the positive effects of physical exercise on the central nervous system and potentially counter degenerative processes during aging and neurodegenerative disorders. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 93 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 19% |
| Student > Master | 13 | 14% |
| Student > Ph. D. Student | 12 | 13% |
| Researcher | 10 | 11% |
| Student > Doctoral Student | 7 | 7% |
| Other | 15 | 16% |
| Unknown | 19 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 25 | 27% |
| Agricultural and Biological Sciences | 9 | 10% |
| Psychology | 8 | 9% |
| Medicine and Dentistry | 8 | 9% |
| Nursing and Health Professions | 7 | 7% |
| Other | 18 | 19% |
| Unknown | 19 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2016.
All research outputs
#3,621,328
of 25,371,288 outputs
Outputs from Brain Structure and Function
#271
of 2,021 outputs
Outputs of similar age
#58,845
of 330,404 outputs
Outputs of similar age from Brain Structure and Function
#3
of 38 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,021 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,404 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.