Title |
The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial
|
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Published in |
BMC Geriatrics, July 2011
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DOI | 10.1186/1471-2318-11-34 |
Pubmed ID | |
Authors |
Annemarieke de Jonghe, Barbara C van Munster, Hannah E van Oosten, J Carel Goslings, Peter Kloen, Carolien van Rees, Reinder Wolvius, Romuald van Velde, Marcel M Levi, Joke C Korevaar, Sophia E de Rooij, the Amsterdam Delirium Study group |
Abstract |
With an ageing population, older persons become a larger part of the hospital population. The incidence of delirium is high in this group, and experiencing delirium has major short- and long-term sequelae, which makes prevention crucial. During delirium, a disruption of the sleep-wake cycle is frequently observed. Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium. The aim of this article is to describe the design of a randomised, placebo controlled double-blind trial that is currently in progress and that investigates the effects of melatonin versus placebo on delirium in older, postoperative hip fracture patients. |
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Geographical breakdown
Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 163 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 21 | 12% |
Student > Ph. D. Student | 20 | 12% |
Student > Master | 20 | 12% |
Student > Doctoral Student | 15 | 9% |
Other | 15 | 9% |
Other | 43 | 25% |
Unknown | 35 | 21% |
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Nursing and Health Professions | 13 | 8% |
Psychology | 11 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Social Sciences | 4 | 2% |
Other | 11 | 7% |
Unknown | 40 | 24% |