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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sex Determination and Gonadal Development in Mammals
|
|---|---|
| Published in |
Physiological Reviews, January 2007
|
| DOI | 10.1152/physrev.00009.2006 |
| Pubmed ID | |
| Authors |
Dagmar Wilhelm, Stephen Palmer, Peter Koopman |
| Abstract |
Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly different journeys of male and female life are thus decided by a genetic coin toss. These differences begin to unfold during fetal development, when the Y-chromosomal Sry ("sex-determining region Y") gene is activated in males and acts as a switch that diverts the fate of the undifferentiated gonadal primordia, the genital ridges, towards testis development. This sex-determining event sets in train a cascade of morphological changes, gene regulation, and molecular interactions that directs the differentiation of male characteristics. If this does not occur, alternative molecular cascades and cellular events drive the genital ridges toward ovary development. Once testis or ovary differentiation has occurred, our sexual fate is further sealed through the action of sex-specific gonadal hormones. We review here the molecular and cellular events (differentiation, migration, proliferation, and communication) that distinguish testis and ovary during fetal development, and the changes in gene regulation that underpin these two alternate pathways. The growing body of knowledge relating to testis development, and the beginnings of a picture of ovary development, together illustrate the complex mechanisms by which these organ systems develop, inform the etiology, diagnosis, and management of disorders of sexual development, and help define what it is to be male or female. |
X Demographics
The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 17% |
| United Kingdom | 5 | 8% |
| Australia | 2 | 3% |
| France | 1 | 2% |
| Bosnia and Herzegovina | 1 | 2% |
| Belarus | 1 | 2% |
| Sri Lanka | 1 | 2% |
| Congo, The Democratic Republic of the | 1 | 2% |
| South Sudan | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 34 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 90% |
| Scientists | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 629 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | <1% |
| Brazil | 5 | <1% |
| United States | 4 | <1% |
| Zimbabwe | 2 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Kazakhstan | 1 | <1% |
| Netherlands | 1 | <1% |
| Czechia | 1 | <1% |
| Other | 7 | 1% |
| Unknown | 601 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 105 | 17% |
| Student > Bachelor | 103 | 16% |
| Student > Master | 95 | 15% |
| Researcher | 72 | 11% |
| Student > Doctoral Student | 39 | 6% |
| Other | 93 | 15% |
| Unknown | 122 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 225 | 36% |
| Biochemistry, Genetics and Molecular Biology | 122 | 19% |
| Medicine and Dentistry | 76 | 12% |
| Veterinary Science and Veterinary Medicine | 18 | 3% |
| Neuroscience | 13 | 2% |
| Other | 34 | 5% |
| Unknown | 141 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 114. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2024.
All research outputs
#377,428
of 25,789,020 outputs
Outputs from Physiological Reviews
#53
of 1,379 outputs
Outputs of similar age
#766
of 170,078 outputs
Outputs of similar age from Physiological Reviews
#1
of 8 outputs
Altmetric has tracked 25,789,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,379 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,078 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them