| Title |
No effect of acute l-arginine supplementation on O2 cost or exercise tolerance
|
|---|---|
| Published in |
European Journal of Applied Physiology, February 2013
|
| DOI | 10.1007/s00421-013-2593-z |
| Pubmed ID | |
| Authors |
Anni Vanhatalo, Stephen J. Bailey, Fred J. DiMenna, Jamie R. Blackwell, Gareth A. Wallis, Andrew M. Jones |
| Abstract |
The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial. This randomised, double blinded, cross-over study investigated the effects of acute ARG supplementation on NO biomarkers, O₂ cost of exercise and exercise tolerance in humans. In one experiment, 15 subjects completed moderate- and severe-intensity running bouts after acute supplementation with 6 g ARG or placebo (PLA). In another experiment, eight subjects completed moderate- and severe-intensity cycling bouts after acute supplementation with 6 g ARG plus 25 g of carbohydrate (ARG + CHO) or an energy-matched dose of carbohydrate alone (CHO). The plasma nitrite concentration was not different after ARG (Pre: 204 ± 79; Post: 241 ± 114 nM; P > 0.05) or ARG + CHO consumption (Pre: 304 ± 57; Post: 335 ± 116 nM; P > 0.05). During moderate-intensity exercise, the steady-state pulmonary VO₂ was not different, relative to the respective placebo conditions, after ARG (PLA: 2,407 ± 318, ARG: 2,422 ± 333 mL min(-1)) or ARG + CHO (CHO: 1,695 ± 304, ARG + CHO: 1,712 ± 312 mL min(-1)) ingestion (P > 0.05). The tolerable duration of severe exercise was also not significantly different (P > 0.05) after ingesting ARG (PLA: 551 ± 140, ARG: 552 ± 150 s) or ARG + CHO (CHO: 457 ± 182, ARG + CHO: 441 ± 221 s). In conclusion, acute dietary supplementation with ARG or ARG + CHO did not alter biomarkers of NO synthesis, O₂ cost of exercise or exercise tolerance in healthy subjects. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 28% |
| United States | 3 | 9% |
| Netherlands | 2 | 6% |
| Australia | 2 | 6% |
| Italy | 2 | 6% |
| Spain | 1 | 3% |
| Switzerland | 1 | 3% |
| Brazil | 1 | 3% |
| Qatar | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 7 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 44% |
| Practitioners (doctors, other healthcare professionals) | 10 | 31% |
| Scientists | 8 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 89 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 20% |
| Student > Bachelor | 18 | 20% |
| Student > Ph. D. Student | 11 | 12% |
| Lecturer > Senior Lecturer | 4 | 4% |
| Professor > Associate Professor | 4 | 4% |
| Other | 14 | 16% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 27 | 30% |
| Medicine and Dentistry | 12 | 13% |
| Nursing and Health Professions | 10 | 11% |
| Agricultural and Biological Sciences | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 8 | 9% |
| Unknown | 23 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2017.
All research outputs
#1,212,156
of 25,374,917 outputs
Outputs from European Journal of Applied Physiology
#380
of 4,345 outputs
Outputs of similar age
#8,805
of 204,953 outputs
Outputs of similar age from European Journal of Applied Physiology
#5
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,345 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,953 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.