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Statin Use Significantly Improves Overall Survival in High-Grade Endometrial Cancer

Overview of attention for article published in International Journal of Gynecological Cancer, November 2016
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Title
Statin Use Significantly Improves Overall Survival in High-Grade Endometrial Cancer
Published in
International Journal of Gynecological Cancer, November 2016
DOI 10.1097/igc.0000000000000819
Pubmed ID
Authors

Christine H. Feng, Charlie M. Miller, Meaghan E. Tenney, Nita K. Lee, S. Diane Yamada, Yasmin Hasan

Abstract

Preclinical data and recent epidemiological studies suggest that statins have antiproliferative and antimetastatic effects in various cancer cells, and reduce cancer mortality and recurrence. We study the effect of statin use on survival outcomes and recurrence rates in patients with endometrial cancer with high-risk histology. All patients receiving definitive therapy for high-risk endometrial cancer from 1995 to 2014 were retrospectively reviewed. Health characteristics at baseline were collected, and statin use was determined from medical records. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method and compared using the log-rank test. Cox proportional hazards regression models were used for univariate and multivariate analysis to determine independent factors associated with OS and PFS. A total of 199 patients were included in the study, of which 76 were hyperlipidemic and 50 used statins. The median follow-up time was 31 months from time of diagnosis. Hyperlipidemic patients who used statins had improved OS compared with hyperlipidemic patients not using statins (hazard ratio, 0.42; 95% confidence interval, 0.20-0.87; P = 0.02). Statin use was also associated with improved PFS (hazard ratio, 0.47; 95% confidence interval, 0.23-0.95; P = 0.04) on multivariate analysis. Hyperlipidemic patients who used statins had borderline improved freedom from local failure compared with hyperlipidemic cases not using statins (P = 0.08, log-rank test). Statin use was not found to be associated with improved cancer-specific mortality. Statin use is independently associated with significant improvements in PFS for the overall group and PFS and OS in the hyperlipidemic group.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 18%
Student > Postgraduate 4 18%
Student > Bachelor 2 9%
Researcher 2 9%
Student > Doctoral Student 1 5%
Other 4 18%
Unknown 5 23%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Pharmacology, Toxicology and Pharmaceutical Science 4 18%
Economics, Econometrics and Finance 1 5%
Business, Management and Accounting 1 5%
Social Sciences 1 5%
Other 1 5%
Unknown 7 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2016.
All research outputs
#18,475,157
of 22,893,031 outputs
Outputs from International Journal of Gynecological Cancer
#1,917
of 3,141 outputs
Outputs of similar age
#235,435
of 311,676 outputs
Outputs of similar age from International Journal of Gynecological Cancer
#27
of 53 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,141 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,676 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.