| Title |
Advanced Glycation End Products, Diabetes, and Bone Strength
|
|---|---|
| Published in |
Current Osteoporosis Reports, October 2016
|
| DOI | 10.1007/s11914-016-0332-1 |
| Pubmed ID | |
| Authors |
Masahiro Yamamoto, Toshitsugu Sugimoto |
| Abstract |
Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), which are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. On the other hand, these compounds biologically act as agonists for these receptors for AGEs (RAGE) and suppress bone metabolism. The concentrations of AGEs and endogenous secretory RAGE, which acts as a "decoy receptor" that inhibits the AGEs-RAGE signaling axis, are associated with fracture risk in a BMD-independent manner. AGEs are closely associated with the pathogenesis of this unique clinical manifestation through physical and biological mechanisms in patients with diabetes mellitus. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Japan | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 148 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 20% |
| Student > Master | 21 | 14% |
| Student > Bachelor | 13 | 9% |
| Researcher | 13 | 9% |
| Student > Doctoral Student | 12 | 8% |
| Other | 27 | 18% |
| Unknown | 32 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 26% |
| Biochemistry, Genetics and Molecular Biology | 20 | 14% |
| Engineering | 11 | 7% |
| Agricultural and Biological Sciences | 7 | 5% |
| Materials Science | 5 | 3% |
| Other | 19 | 13% |
| Unknown | 47 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2022.
All research outputs
#1,740,782
of 23,426,104 outputs
Outputs from Current Osteoporosis Reports
#28
of 563 outputs
Outputs of similar age
#32,426
of 321,577 outputs
Outputs of similar age from Current Osteoporosis Reports
#2
of 11 outputs
Altmetric has tracked 23,426,104 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 563 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.