| Title |
Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study
|
|---|---|
| Published in |
BMC Medical Genomics, January 2013
|
| DOI | 10.1186/1471-2350-14-4 |
| Pubmed ID | |
| Authors |
M Cristina Kenney, Dieter Hertzog, Garrick Chak, Shari R Atilano, Nikan Khatibi, Kyaw Soe, Andrew Nobe, Elizabeth Yang, Marilyn Chwa, Feilin Zhu, Masood Memarzadeh, Jacqueline King, Jonathan Langberg, Kent Small, Anthony B Nesburn, David S Boyer, Nitin Udar |
| Abstract |
Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly, Caucasian populations. There is strong evidence that mitochondrial dysfunction and oxidative stress play a role in the cell death found in AMD retinas. The purpose of this study was to examine the association of the Caucasian mitochondrial JTU haplogroup cluster with AMD. We also assessed for gender bias and additive risk with known high risk nuclear gene SNPs, ARMS2/LOC387715 (G > T; Ala69Ser, rs10490924) and CFH (T > C; Try402His, rs1061170). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ecuador | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 2% |
| Italy | 1 | 2% |
| Unknown | 53 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 20% |
| Student > Doctoral Student | 8 | 15% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 5 | 9% |
| Student > Postgraduate | 5 | 9% |
| Other | 12 | 22% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 29% |
| Agricultural and Biological Sciences | 13 | 24% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Neuroscience | 3 | 5% |
| Psychology | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 10 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2013.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from BMC Medical Genomics
#1,315
of 2,444 outputs
Outputs of similar age
#194,462
of 290,318 outputs
Outputs of similar age from BMC Medical Genomics
#25
of 40 outputs
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