| Title |
Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging
|
|---|---|
| Published in |
Brain Imaging and Behavior, October 2016
|
| DOI | 10.1007/s11682-016-9598-2 |
| Pubmed ID | |
| Authors |
Jennifer S. Yokoyama, Gabe Marx, Jesse A. Brown, Luke W. Bonham, Dan Wang, Giovanni Coppola, William W. Seeley, Howard J. Rosen, Bruce L. Miller, Joel H. Kramer, Dena B. Dubal |
| Abstract |
Cognitive decline is a major biomedical challenge as the global population ages. Elevated levels of the longevity factor klotho suppress aging, enhance cognition, and promote synaptic plasticity and neural resilience against aging and Alzheimer's disease (AD)-related pathogenic proteins. Here, we examined the relationship between human genetic variants of KLOTHO and systemic klotho levels - and assessed neuroanatomic correlates of serum klotho in a cohort of healthy older adults. Serum klotho levels were increased with KL-VS heterozygosity, as anticipated. We report, for the first time, that serum klotho levels were paradoxically decreased with KL-VS homozygosity. Further, we found that higher serum klotho levels were associated with measures of greater intrinsic connectivity in key functional networks of the brain vulnerable to aging and AD such as the fronto-parietal and default mode networks. Our findings suggest that elevated klotho promotes a resilient brain, possibly through increased network connectivity of critical brain regions. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 16% |
| Student > Bachelor | 10 | 12% |
| Student > Master | 9 | 10% |
| Researcher | 8 | 9% |
| Student > Doctoral Student | 7 | 8% |
| Other | 14 | 16% |
| Unknown | 24 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 19% |
| Medicine and Dentistry | 15 | 17% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Nursing and Health Professions | 6 | 7% |
| Psychology | 5 | 6% |
| Other | 9 | 10% |
| Unknown | 29 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2022.
All research outputs
#1,943,262
of 23,299,593 outputs
Outputs from Brain Imaging and Behavior
#91
of 1,155 outputs
Outputs of similar age
#35,854
of 321,229 outputs
Outputs of similar age from Brain Imaging and Behavior
#5
of 57 outputs
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So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.