Title |
Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study
|
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Published in |
Journal of Autism and Developmental Disorders, October 2016
|
DOI | 10.1007/s10803-016-2914-2 |
Pubmed ID | |
Authors |
Agnieszka Butwicka, Niklas Långström, Henrik Larsson, Sebastian Lundström, Eva Serlachius, Catarina Almqvist, Louise Frisén, Paul Lichtenstein |
Abstract |
Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973-2009, and their 96,557 non-ASD relatives. ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. The risk of substance use-related problems was the highest among individuals with ASD and ADHD. Further, risks of substance use-related problems were increased among full siblings of ASD probands, half-siblings and parents. We conclude that ASD is a risk factor for substance use-related problems. The elevated risks among relatives of probands with ASD suggest shared familial (genetic and/or shared environmental) liability. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 9 | 18% |
Japan | 3 | 6% |
Germany | 2 | 4% |
Spain | 2 | 4% |
United Kingdom | 2 | 4% |
Canada | 1 | 2% |
Mexico | 1 | 2% |
Australia | 1 | 2% |
Sweden | 1 | 2% |
Other | 0 | 0% |
Unknown | 29 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 44 | 86% |
Scientists | 3 | 6% |
Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 201 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 30 | 15% |
Researcher | 24 | 12% |
Student > Ph. D. Student | 24 | 12% |
Student > Bachelor | 17 | 8% |
Student > Doctoral Student | 13 | 6% |
Other | 40 | 20% |
Unknown | 55 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 48 | 24% |
Medicine and Dentistry | 33 | 16% |
Social Sciences | 16 | 8% |
Neuroscience | 11 | 5% |
Nursing and Health Professions | 10 | 5% |
Other | 24 | 12% |
Unknown | 61 | 30% |