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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure and Dynamic Regulation of Abl Kinases*
|
|---|---|
| Published in |
Journal of Biological Chemistry, January 2013
|
| DOI | 10.1074/jbc.r112.438382 |
| Pubmed ID | |
| Authors |
Shoghag Panjarian, Roxana E. Iacob, Shugui Chen, John R. Engen, Thomas E. Smithgall |
| Abstract |
The c-abl proto-oncogene encodes a unique protein-tyrosine kinase (Abl) distinct from c-Src, c-Fes, and other cytoplasmic tyrosine kinases. In normal cells, Abl plays prominent roles in cellular responses to genotoxic stress as well as in the regulation of the actin cytoskeleton. Abl is also well known in the context of Bcr-Abl, the oncogenic fusion protein characteristic of chronic myelogenous leukemia. Selective inhibitors of Bcr-Abl, of which imatinib is the prototype, have had a tremendous impact on clinical outcomes in chronic myelogenous leukemia and revolutionized the field of targeted cancer therapy. In this minireview, we focus on the structural organization and dynamics of Abl kinases and how these features influence inhibitor sensitivity. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Switzerland | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 213 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 17% |
| Student > Master | 34 | 15% |
| Student > Bachelor | 34 | 15% |
| Researcher | 28 | 13% |
| Student > Doctoral Student | 13 | 6% |
| Other | 33 | 15% |
| Unknown | 41 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 24% |
| Biochemistry, Genetics and Molecular Biology | 46 | 21% |
| Chemistry | 33 | 15% |
| Medicine and Dentistry | 12 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
| Other | 18 | 8% |
| Unknown | 48 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#7,355,930
of 25,373,627 outputs
Outputs from Journal of Biological Chemistry
#29,737
of 85,238 outputs
Outputs of similar age
#73,027
of 290,080 outputs
Outputs of similar age from Journal of Biological Chemistry
#132
of 566 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 85,238 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,080 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 566 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.