| Title |
Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD)
|
|---|---|
| Published in |
Brain Imaging and Behavior, October 2016
|
| DOI | 10.1007/s11682-016-9624-4 |
| Pubmed ID | |
| Authors |
Jeffrey R. Wozniak, Bryon A. Mueller, Sarah N. Mattson, Claire D. Coles, Julie A. Kable, Kenneth L. Jones, Christopher J. Boys, Kelvin O. Lim, Edward P. Riley, Elizabeth R. Sowell, the CIFASD |
| Abstract |
Consistent with well-documented structural and microstructural abnormalities in prenatal alcohol exposure (PAE), recent studies suggest that functional connectivity (FC) may also be disrupted. We evaluated whole-brain FC in a large multi-site sample, examined its cognitive correlates, and explored its potential to objectively identify neurodevelopmental abnormality in individuals without definitive dysmorphic features. Included were 75 children with PAE and 68 controls from four sites. All participants had documented heavy prenatal alcohol exposure. All underwent a formal evaluation of physical anomalies and dysmorphic facial features. MRI data were collected using modified matched protocols on three platforms (Siemens, GE, and Philips). Resting-state FC was examined using whole-brain graph theory metrics to characterize each individual's connectivity. Although whole-brain FC metrics did not discriminate prenatally-exposed from unexposed overall, atypical FC (> 1 standard deviation from the grand mean) was significantly more common (2.7 times) in the PAE group vs. In a subset of 55 individuals (PAE and controls) whose dysmorphology examination could not definitively characterize them as either Fetal Alcohol Syndrome (FAS) or non-FAS, atypical FC was seen in 27 % of the PAE group, but 0 % of controls. Across participants, a 1 % difference in local network efficiency was associated with a 36 point difference in global cognitive functioning. Whole-brain FC metrics have potential to identify individuals with objective neurodevelopmental abnormalities from prenatal alcohol exposure. When applied to individuals unable to be classified as FAS or non-FAS from dysmorphology alone, these measures separate prenatally-exposed from non-exposed with high specificity. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 13% |
| Researcher | 13 | 12% |
| Student > Bachelor | 12 | 11% |
| Student > Ph. D. Student | 11 | 10% |
| Student > Doctoral Student | 10 | 9% |
| Other | 21 | 19% |
| Unknown | 27 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 16% |
| Psychology | 16 | 15% |
| Medicine and Dentistry | 16 | 15% |
| Computer Science | 6 | 6% |
| Agricultural and Biological Sciences | 6 | 6% |
| Other | 15 | 14% |
| Unknown | 32 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2017.
All research outputs
#14,275,152
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Outputs from Brain Imaging and Behavior
#558
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Outputs of similar age
#181,958
of 319,855 outputs
Outputs of similar age from Brain Imaging and Behavior
#25
of 57 outputs
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