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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Overview of attention for article published in Brain Imaging and Behavior, October 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

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1 blog
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31 X users
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4 Facebook pages

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152 Dimensions

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492 Mendeley
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1 CiteULike
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Title
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
Published in
Brain Imaging and Behavior, October 2016
DOI 10.1007/s11682-016-9629-z
Pubmed ID
Authors

Tulio Guadalupe, Samuel R. Mathias, Theo G. M. vanErp, Christopher D. Whelan, Marcel P. Zwiers, Yoshinari Abe, Lucija Abramovic, Ingrid Agartz, Ole A. Andreassen, Alejandro Arias-Vásquez, Benjamin S. Aribisala, Nicola J. Armstrong, Volker Arolt, Eric Artiges, Rosa Ayesa-Arriola, Vatche G. Baboyan, Tobias Banaschewski, Gareth Barker, Mark E. Bastin, Bernhard T. Baune, John Blangero, Arun L.W. Bokde, Premika S.W. Boedhoe, Anushree Bose, Silvia Brem, Henry Brodaty, Uli Bromberg, Samantha Brooks, Christian Büchel, Jan Buitelaar, Vince D. Calhoun, Dara M. Cannon, Anna Cattrell, Yuqi Cheng, Patricia J. Conrod, Annette Conzelmann, Aiden Corvin, Benedicto Crespo-Facorro, Fabrice Crivello, Udo Dannlowski, Greig I. de Zubicaray, Sonja M.C. de Zwarte, Ian J. Deary, Sylvane Desrivières, Nhat Trung Doan, Gary Donohoe, Erlend S. Dørum, Stefan Ehrlich, Thomas Espeseth, Guillén Fernández, Herta Flor, Jean-Paul Fouche, Vincent Frouin, Masaki Fukunaga, Jürgen Gallinat, Hugh Garavan, Michael Gill, Andrea Gonzalez Suarez, Penny Gowland, Hans J. Grabe, Dominik Grotegerd, Oliver Gruber, Saskia Hagenaars, Ryota Hashimoto, Tobias U. Hauser, Andreas Heinz, Derrek P. Hibar, Pieter J. Hoekstra, Martine Hoogman, Fleur M. Howells, Hao Hu, Hilleke E. Hulshoff Pol, Chaim Huyser, Bernd Ittermann, Neda Jahanshad, Erik G. Jönsson, Sarah Jurk, Rene S. Kahn, Sinead Kelly, Bernd Kraemer, Harald Kugel, Jun Soo Kwon, Herve Lemaitre, Klaus-Peter Lesch, Christine Lochner, Michelle Luciano, Andre F. Marquand, Nicholas G. Martin, Ignacio Martínez-Zalacaín, Jean-Luc Martinot, David Mataix-Cols, Karen Mather, Colm McDonald, Katie L. McMahon, Sarah E. Medland, José M. Menchón, Derek W. Morris, Omar Mothersill, Susana Munoz Maniega, Benson Mwangi, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswaamy, Frauke Nees, Jan E. Nordvik, A. Marten H. Onnink, Nils Opel, Roel Ophoff, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Paul Pauli, Tomáš Paus, Luise Poustka, Janardhan YC. Reddy, Miguel E. Renteria, Roberto Roiz-Santiáñez, Annerine Roos, Natalie A. Royle, Perminder Sachdev, Pascual Sánchez-Juan, Lianne Schmaal, Gunter Schumann, Elena Shumskaya, Michael N. Smolka, Jair C. Soares, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Roberto Toro, Jessica A. Turner, Nathalie Tzourio-Mazoyer, Anne Uhlmann, Maria Valdés Hernández, Odile A. van den Heuvel, Dennis van der Meer, Neeltje E.M . van Haren, Dick J. Veltman, Ganesan Venkatasubramanian, Nora C. Vetter, Daniella Vuletic, Susanne Walitza, Henrik Walter, Esther Walton, Zhen Wang, Joanna Wardlaw, Wei Wen, Lars T. Westlye, Robert Whelan, Katharina Wittfeld, Thomas Wolfers, Margaret J. Wright, Jian Xu, Xiufeng Xu, Je-Yeon Yun, JingJing Zhao, Barbara Franke, Paul M. Thompson, David C. Glahn, Bernard Mazoyer, Simon E. Fisher, Clyde Francks

Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

X Demographics

X Demographics

The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 492 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
Netherlands 1 <1%
China 1 <1%
Germany 1 <1%
Unknown 484 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 75 15%
Student > Master 65 13%
Student > Ph. D. Student 63 13%
Student > Bachelor 31 6%
Student > Doctoral Student 23 5%
Other 86 17%
Unknown 149 30%
Readers by discipline Count As %
Medicine and Dentistry 79 16%
Psychology 66 13%
Neuroscience 54 11%
Nursing and Health Professions 39 8%
Biochemistry, Genetics and Molecular Biology 15 3%
Other 56 11%
Unknown 183 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2019.
All research outputs
#1,344,231
of 25,448,590 outputs
Outputs from Brain Imaging and Behavior
#63
of 1,184 outputs
Outputs of similar age
#24,075
of 325,906 outputs
Outputs of similar age from Brain Imaging and Behavior
#2
of 58 outputs
Altmetric has tracked 25,448,590 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,184 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.