| Title |
Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission
|
|---|---|
| Published in |
Obesity Surgery, October 2016
|
| DOI | 10.1007/s11695-016-2399-2 |
| Pubmed ID | |
| Authors |
Rinki Murphy, Peter Tsai, Mia Jüllig, Amy Liu, Lindsay Plank, Michael Booth |
| Abstract |
It is unclear whether specific gut microbiota is associated with remission of type 2 diabetes (T2D) after distinct types of bariatric surgery. The aim of this study is to examine gut microbiota changes after laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery in obese patients with T2D. Whole-metagenome shotgun sequencing of DNA fragments using Illumina HiSeq2000 was obtained from stool samples collected from 14 obese T2D patients pre-operatively (while on very low calorie diet) and 1 year after randomisation to laparoscopic SG (n = 7) or RYGB (n = 7). Resulting shotgun reads were annotated with Kyoto Encyclopedia of Genes and Genomes (KEGG). Body weight reduction and dietary change was similar 1 year after both surgery types. Identical proportions (n = 5/7) achieved diabetes remission (HbA1c < 48 mmol/mol without medications) 1 year after RYGB and SG. RYGB resulted in increased Firmicutes and Actinobacteria phyla but decreased Bacteroidetes phyla. SG resulted in increased Bacteroidetes phyla. Only an increase in Roseburia species was observed among those achieving diabetes remission, common to both surgery types. KEGG Orthology and pathway analysis predicted contrasting and greater gut microbiota metabolism changes after diabetes remission following RYGB than after SG. Those with persistent diabetes post-operatively had higher Desulfovibrio species pre-operatively. Overall, RYGB produces greater and more predicted favourable changes in gut microbiota functional capacity than SG. An increase in Roseburia species was the only compositional change common to both types of surgery among those achieving diabetes remission. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 20% |
| Saudi Arabia | 2 | 10% |
| Mexico | 1 | 5% |
| New Zealand | 1 | 5% |
| India | 1 | 5% |
| Canada | 1 | 5% |
| United Kingdom | 1 | 5% |
| Spain | 1 | 5% |
| Colombia | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 55% |
| Practitioners (doctors, other healthcare professionals) | 4 | 20% |
| Scientists | 4 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 337 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 337 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 56 | 17% |
| Student > Bachelor | 51 | 15% |
| Student > Master | 39 | 12% |
| Student > Ph. D. Student | 29 | 9% |
| Student > Postgraduate | 20 | 6% |
| Other | 52 | 15% |
| Unknown | 90 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 98 | 29% |
| Biochemistry, Genetics and Molecular Biology | 25 | 7% |
| Agricultural and Biological Sciences | 22 | 7% |
| Nursing and Health Professions | 18 | 5% |
| Immunology and Microbiology | 11 | 3% |
| Other | 45 | 13% |
| Unknown | 118 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2017.
All research outputs
#1,690,483
of 24,171,551 outputs
Outputs from Obesity Surgery
#143
of 3,572 outputs
Outputs of similar age
#30,638
of 324,227 outputs
Outputs of similar age from Obesity Surgery
#3
of 72 outputs
Altmetric has tracked 24,171,551 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,572 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.