Title |
Causes of variation in the neutrophillymphocyte and plateletlymphocyte ratios: a twin-family study
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Published in |
Biomarkers in Medicine, October 2016
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DOI | 10.2217/bmm-2016-0147 |
Pubmed ID | |
Authors |
Bochao D Lin, Jouke-Jan Hottenga, Abdel Abdellaoui, Conor V Dolan, Eco J C de Geus, Cornelis Kluft, Dorret I Boomsma, Gonneke Willemsen |
Abstract |
Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are biomarkers for disease development, for whom little is known about causes of variation in the general population. We estimated the heritability of PLR and NLR and examined their association with gender, demographic, lifestyle and environmental factors in a Dutch nonpatient twin family population (n = 8108). Heritability was estimated at 64% for PLR and 36% for NLR. Men had on average higher NLR, but lower PLR levels than women. PLR and NLR increased significantly with age, decreased in colder months and showed small but significant sex- and age-specific associations with body composition and smoking. NLR and PLR levels are heritable and influenced by age, sex and environmental factors, such as seasonal conditions and lifestyle. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 19% |
Student > Ph. D. Student | 7 | 10% |
Student > Master | 5 | 7% |
Researcher | 5 | 7% |
Other | 5 | 7% |
Other | 8 | 11% |
Unknown | 27 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 31% |
Nursing and Health Professions | 5 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Psychology | 2 | 3% |
Other | 4 | 6% |
Unknown | 31 | 44% |