| Title |
Is Depression an Inflammatory Disorder?
|
|---|---|
| Published in |
Current Psychiatry Reports, September 2011
|
| DOI | 10.1007/s11920-011-0232-0 |
| Pubmed ID | |
| Authors |
Charles L. Raison, Andrew H. Miller |
| Abstract |
Studies consistently report that groups of individuals with major depressive disorder (MDD) demonstrate increased levels of a variety of peripheral inflammatory biomarkers when compared with groups of nondepressed individuals. These findings are often interpreted as meaning that MDD, even in medically healthy individuals, may be an inflammatory condition. In this article, we examine evidence for and against this idea by looking more closely into what the actual patterns of inflammatory findings indicate in terms of the relationship between MDD and the immune system. Data are presented in support of the idea that inflammation only contributes to depression in a subset of patients versus the possibility that the depressogenic effect of inflammatory activation is more widespread and varies depending on the degree of vulnerability any given individual evinces in interconnected physiologic systems known to be implicated in the etiology of MDD. Finally, the treatment implications of these various possibilities are discussed. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 30% |
| Mexico | 3 | 13% |
| United Kingdom | 3 | 13% |
| Spain | 1 | 4% |
| India | 1 | 4% |
| Unknown | 8 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 70% |
| Practitioners (doctors, other healthcare professionals) | 4 | 17% |
| Scientists | 2 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 576 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| United States | 3 | <1% |
| Brazil | 2 | <1% |
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| Chile | 1 | <1% |
| Switzerland | 1 | <1% |
| Hungary | 1 | <1% |
| Canada | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 559 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 99 | 17% |
| Student > Bachelor | 91 | 16% |
| Student > Ph. D. Student | 85 | 15% |
| Researcher | 70 | 12% |
| Student > Doctoral Student | 40 | 7% |
| Other | 99 | 17% |
| Unknown | 92 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 122 | 21% |
| Psychology | 99 | 17% |
| Neuroscience | 57 | 10% |
| Agricultural and Biological Sciences | 55 | 10% |
| Biochemistry, Genetics and Molecular Biology | 26 | 5% |
| Other | 89 | 15% |
| Unknown | 128 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 111. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2022.
All research outputs
#368,770
of 25,013,816 outputs
Outputs from Current Psychiatry Reports
#56
of 1,267 outputs
Outputs of similar age
#1,285
of 134,993 outputs
Outputs of similar age from Current Psychiatry Reports
#2
of 9 outputs
Altmetric has tracked 25,013,816 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,267 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.