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Diagnostic Test Accuracy in Childhood Pulmonary Tuberculosis: A Bayesian Latent Class Analysis

Overview of attention for article published in American Journal of Epidemiology, November 2016
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Title
Diagnostic Test Accuracy in Childhood Pulmonary Tuberculosis: A Bayesian Latent Class Analysis
Published in
American Journal of Epidemiology, November 2016
DOI 10.1093/aje/kww094
Pubmed ID
Authors

Samuel G. Schumacher, Maarten van Smeden, Nandini Dendukuri, Lawrence Joseph, Mark P. Nicol, Madhukar Pai, Heather J. Zar

Abstract

Evaluation of tests for the diagnosis of childhood pulmonary tuberculosis (CPTB) is complicated by the absence of an accurate reference test. We present a Bayesian latent class analysis in which we evaluated the accuracy of 5 diagnostic tests for CPTB. We used data from a study of 749 hospitalized South African children suspected to have CPTB from 2009 to 2014. The following tests were used: mycobacterial culture, smear microscopy, Xpert MTB/RIF (Cepheid Inc.), tuberculin skin test (TST), and chest radiography. We estimated the prevalence of CPTB to be 27% (95% credible interval (CrI): 21, 35). The sensitivities of culture, Xpert, and smear microscopy were estimated to be 60% (95% CrI: 46, 76), 49% (95% CrI: 38, 62), and 22% (95% CrI: 16, 30), respectively; specificities of these tests were estimated in accordance with prior information and were close to 100%. Chest radiography was estimated to have a sensitivity of 64% (95% CrI: 55, 73) and a specificity of 78% (95% CrI: 73, 83). Sensitivity of the TST was estimated to be 75% (95% CrI: 61, 84), and it decreased substantially among children who were malnourished and infected with human immunodeficiency virus (56%). The specificity of the TST was 69% (95% CrI: 63%, 76%). Furthermore, it was estimated that 46% (95% CrI: 42, 49) of CPTB-negative cases and 93% (95% CrI: 82; 98) of CPTB-positive cases received antituberculosis treatment, which indicates substantial overtreatment and limited undertreatment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 127 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 20%
Student > Master 23 18%
Student > Ph. D. Student 13 10%
Student > Bachelor 10 8%
Other 8 6%
Other 26 20%
Unknown 23 18%
Readers by discipline Count As %
Medicine and Dentistry 51 40%
Nursing and Health Professions 9 7%
Biochemistry, Genetics and Molecular Biology 7 5%
Immunology and Microbiology 7 5%
Mathematics 5 4%
Other 18 14%
Unknown 31 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2022.
All research outputs
#6,210,515
of 24,489,824 outputs
Outputs from American Journal of Epidemiology
#4,328
of 9,296 outputs
Outputs of similar age
#88,618
of 317,123 outputs
Outputs of similar age from American Journal of Epidemiology
#31
of 60 outputs
Altmetric has tracked 24,489,824 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 9,296 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,123 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.