| Title |
Neuroinflammation, immune system and Alzheimer disease: searching for the missing link
|
|---|---|
| Published in |
Aging Clinical and Experimental Research, October 2016
|
| DOI | 10.1007/s40520-016-0637-z |
| Pubmed ID | |
| Authors |
F. Guerriero, C. Sgarlata, M. Francis, N. Maurizi, A. Faragli, S. Perna, M. Rondanelli, M. Rollone, G. Ricevuti |
| Abstract |
Due to an increasingly aging population, Alzheimer disease (AD) represents a crucial issue for the healthcare system because of its widespread prevalence and the burden of its care needs. Several hypotheses on AD pathogenesis have been proposed and current therapeutical strategies have shown limited effectiveness. In the last decade, more evidence has supported a role for neuroinflammation and immune system dysregulation in AD. It remains unclear whether astrocytes, microglia and immune cells influence disease onset, progression or both. Amyloid-β peptides that aggregate extracellularly in the typical neuritic plaques generate a constant inflammatory environment. This causes a prolonged activation of microglial and astroglial cells that potentiate neuronal damage and provoke the alteration of the blood brain barrier (BBB), damaging the permeability of blood vessels. Recent data support the role of the BBB as a link between neuroinflammation, the immune system and AD. Hence, a thorough investigation of the neuroinflammatory and immune system pathways that impact neurodegeneration and novel exciting findings such as microglia-derived microvesicles, inflammasomes and signalosomes will ultimately enhance our understanding of the pathological process. Eventually, we should proceed with caution in defining a causal or consequential role of neuroinflammation in AD, but rather focus on identifying its exact pathological contribution. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Greece | 1 | <1% |
| Czechia | 1 | <1% |
| Unknown | 146 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 20% |
| Student > Bachelor | 30 | 20% |
| Student > Master | 21 | 14% |
| Researcher | 20 | 13% |
| Other | 6 | 4% |
| Other | 17 | 11% |
| Unknown | 26 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 34 | 23% |
| Agricultural and Biological Sciences | 27 | 18% |
| Biochemistry, Genetics and Molecular Biology | 26 | 17% |
| Medicine and Dentistry | 11 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 16 | 11% |
| Unknown | 31 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2017.
All research outputs
#3,710,488
of 25,374,917 outputs
Outputs from Aging Clinical and Experimental Research
#300
of 1,867 outputs
Outputs of similar age
#60,507
of 327,754 outputs
Outputs of similar age from Aging Clinical and Experimental Research
#3
of 23 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,867 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.