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History of Gestational Diabetes Mellitus and Risk of Incident Invasive Breast Cancer among Parous Women in the Nurses' Health Study II Prospective Cohort

Overview of attention for article published in Cancer Epidemiology, Biomarkers & Prevention, March 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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21 news outlets
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1 X user

Citations

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22 Dimensions

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73 Mendeley
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Title
History of Gestational Diabetes Mellitus and Risk of Incident Invasive Breast Cancer among Parous Women in the Nurses' Health Study II Prospective Cohort
Published in
Cancer Epidemiology, Biomarkers & Prevention, March 2017
DOI 10.1158/1055-9965.epi-16-0601
Pubmed ID
Authors

Camille E Powe, Deirdre K Tobias, Karin B Michels, Wendy Y Chen, A Heather Eliassen, JoAnn E Manson, Bernard Rosner, Walter C Willett, Frank B Hu, Cuilin Zhang, Janet W Rich-Edwards, Kathryn M Rexrode

Abstract

Type 2 diabetes is associated with breast cancer in epidemiologic studies. Pregnancy also modifies breast cancer risk. We hypothesized that women with a history of gestational diabetes mellitus (GDM), which shares pathogenesis and risk factors with type 2 diabetes, would have greater invasive breast cancer risk than parous women without a history of GDM. We conducted a prospective analysis among parous women in the Nurses' Health Study II, with mean age 35 years in 1989. Multivariate Cox proportional hazard models were used to compare risks of incident invasive breast cancer in women with and without a history of GDM. Among 86,972 women studied, 5,188 women reported a history of GDM and 2,377 developed invasive breast cancer (100 with history of GDM, 2277 without GDM) over 22 years of prospective follow-up. History of GDM was inversely associated with incident invasive breast cancer (HR 0.68, 95% CI 0.55-0.84, p=0.0004), compared with no history of GDM, after adjustment for body mass index, reproductive history, and other breast cancer risk factors. Findings were similar by menopausal status, although observed person-time was predominantly premenopausal (premenopausal: HR 0.73, 95% CI 0.56-0.96, p=0.03; postmenopausal: HR 0.63, 95% CI 0.43-0.92, p=0.02). Restricting to women undergoing mammography screening modestly attenuated the relationship (HR 0.74, 95% CI 0.57-0.96, p=0.02). Among a large cohort of US women, history of GDM was not associated with an elevated risk of subsequent invasive breast cancer. Our findings highlight the need to further investigate GDM's role in breast cancer development.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 15%
Student > Bachelor 10 14%
Student > Master 8 11%
Student > Ph. D. Student 7 10%
Student > Postgraduate 5 7%
Other 8 11%
Unknown 24 33%
Readers by discipline Count As %
Medicine and Dentistry 19 26%
Nursing and Health Professions 7 10%
Biochemistry, Genetics and Molecular Biology 4 5%
Agricultural and Biological Sciences 3 4%
Neuroscience 2 3%
Other 11 15%
Unknown 27 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 159. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2017.
All research outputs
#257,289
of 25,377,790 outputs
Outputs from Cancer Epidemiology, Biomarkers & Prevention
#95
of 4,849 outputs
Outputs of similar age
#5,503
of 324,443 outputs
Outputs of similar age from Cancer Epidemiology, Biomarkers & Prevention
#3
of 104 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,849 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.