| Title |
miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells
|
|---|---|
| Published in |
Archives of Pharmacal Research, February 2013
|
| DOI | 10.1007/s12272-013-0067-9 |
| Pubmed ID | |
| Authors |
Jung Ki Yoo, Ho Yong Jung, Chang-Hyun Kim, Woo Sung Son, Jin Kyeoung Kim |
| Abstract |
MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate gene expression through binding to 3' untranslated region. We identified and characterized the novel miRNA, miR-7641, in human mesenchymal stem cells. The expression of miR-7641 was downregulated during differentiation from human embryonic stem cells to endothelial cells. The CXCL1, a member of the CXC chemokine family, is known as promoting neovascularization by binding G-protein coupled receptors and is related to endothelial cells biogenesis such as angiogenesis, and it was predicted as target gene of miR-7641 by computerized analysis and the luciferase reporter assay. The miR-7641 significantly suppressed CXCL1 of transcriptional and post-translational levels. These data suggest that miR-7641 might be related with differentiation of human endothelial cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 4% |
| Unknown | 24 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 20% |
| Student > Doctoral Student | 4 | 16% |
| Student > Master | 4 | 16% |
| Student > Ph. D. Student | 3 | 12% |
| Professor | 2 | 8% |
| Other | 4 | 16% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 28% |
| Biochemistry, Genetics and Molecular Biology | 5 | 20% |
| Medicine and Dentistry | 3 | 12% |
| Immunology and Microbiology | 2 | 8% |
| Psychology | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 7 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2013.
All research outputs
#18,331,227
of 22,699,621 outputs
Outputs from Archives of Pharmacal Research
#1,042
of 1,293 outputs
Outputs of similar age
#146,777
of 192,966 outputs
Outputs of similar age from Archives of Pharmacal Research
#29
of 34 outputs
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