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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
|
|---|---|
| Published in |
Neurobiology of Aging, October 2016
|
| DOI | 10.1016/j.neurobiolaging.2016.09.022 |
| Pubmed ID | |
| Authors |
Lisa Wang, Michael G. Heckman, Jan O. Aasly, Grazia Annesi, Maria Bozi, Sun Ju Chung, Carl Clarke, David Crosiers, Gertrud Eckstein, Gaetan Garraux, Georgios M. Hadjigeorgiou, Nobu Hattori, Beom Jeon, Yun J. Kim, Masato Kubo, Suzanne Lesage, Juei Jueng Lin, Timothy Lynch, Peter Lichtner, George D. Mellick, Vincent Mok, Karin E. Morrison, Aldo Quattrone, Wataru Satake, Peter A. Silburn, Leonidas Stefanis, Joanne D. Stockton, Eng King Tan, Tatsushi Toda, Alexis Brice, Christine Van Broeckhoven, Ryan J. Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Georgia Xiromerisiou, Demetrius M. Maraganore, Thomas Gasser, Rejko Krüger, Matthew J. Farrer, Owen A. Ross, Manu Sharma, GEOPD Consortium |
| Abstract |
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 19% |
| Other | 8 | 15% |
| Student > Ph. D. Student | 5 | 9% |
| Professor | 5 | 9% |
| Student > Bachelor | 4 | 7% |
| Other | 11 | 20% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 20% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Medicine and Dentistry | 7 | 13% |
| Agricultural and Biological Sciences | 4 | 7% |
| Psychology | 3 | 6% |
| Other | 6 | 11% |
| Unknown | 16 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2016.
All research outputs
#3,625,813
of 25,394,764 outputs
Outputs from Neurobiology of Aging
#1,444
of 4,418 outputs
Outputs of similar age
#58,788
of 327,259 outputs
Outputs of similar age from Neurobiology of Aging
#44
of 72 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.