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Cell Death or Survival Promoted by Alternative Isoforms of ErbB4

Overview of attention for article published in Molecular Biology of the Cell, October 2010
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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1 X user
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2 Wikipedia pages

Citations

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53 Dimensions

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66 Mendeley
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Title
Cell Death or Survival Promoted by Alternative Isoforms of ErbB4
Published in
Molecular Biology of the Cell, October 2010
DOI 10.1091/mbc.e10-04-0332
Pubmed ID
Authors

Maria Sundvall, Ville Veikkolainen, Kari Kurppa, Zaidoun Salah, Denis Tvorogov, E. Joop van Zoelen, Rami Aqeilan, Klaus Elenius

Abstract

The significance of ErbB4 in tumor biology is poorly understood. The ERBB4 gene is alternatively spliced producing juxtamembrane (JM-a and JM-b) and cytoplasmic (CYT-1 and CYT-2) isoforms. Here, signaling via the two alternative ErbB4 JM isoforms (JM-a CYT-2 and JM-b CYT-2) was compared. Fibroblasts expressing ErbB4 JM-a demonstrated enhanced ErbB4 autophosphorylation, growth, and survival. In contrast, cells overexpressing ErbB4 JM-b underwent starvation-induced death. Both pro- and antisurvival responses to the two ErbB4 isoforms were sensitive to an ErbB kinase inhibitor. Platelet-derived growth factor receptor-alpha (PDGFRA) was identified as an ErbB4 target gene that was differentially regulated by the two ErbB4 isoforms. The soluble intracellular domain of ErbB4, released from the JM-a but not from the JM-b isoform, associated with the transcription factor AP-2 and promoted its potential to enhance PDGFRA transcription. Survival of cells expressing JM-a was suppressed by targeting either PDGFR-α or AP-2, whereas cells expressing JM-b were rescued from cell death by the PDGFR-α agonist, PDGF-BB. These findings indicate that two alternative ErbB4 isoforms may promote antagonistic cellular responses and suggest that pharmacological inhibition of ErbB4 kinase activity may lead to either suppression or promotion of cellular growth.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Poland 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 35%
Researcher 19 29%
Professor > Associate Professor 5 8%
Student > Master 5 8%
Student > Bachelor 3 5%
Other 5 8%
Unknown 6 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 41%
Biochemistry, Genetics and Molecular Biology 17 26%
Medicine and Dentistry 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Neuroscience 2 3%
Other 4 6%
Unknown 7 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2019.
All research outputs
#7,959,659
of 25,373,627 outputs
Outputs from Molecular Biology of the Cell
#1,911
of 5,478 outputs
Outputs of similar age
#37,030
of 107,989 outputs
Outputs of similar age from Molecular Biology of the Cell
#8
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 5,478 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,989 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.