Title |
Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-1 in node-positive tissue
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Published in |
Personalized Medicine, October 2016
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DOI | 10.2217/pme-2016-0032 |
Pubmed ID | |
Authors |
Vesna Ivanovi, Nasta Dedovi-Tani, Zorka Milovanovi, Silvana Luki, Srdjan Nikoli, Vladimir Balti, Bratislav Stojiljkovi, Miroslav Demajo, Vesna Mandui, Bogomir Dimitrijevi |
Abstract |
We present herein a case report style article on a rare advanced triple-negative breast cancer (TNBC) patient with 6-month disease-free interval, and 10-month overall survival. Our results demonstrate that the poor clinical outcome of this patient was associated with pronounced, more than fivefold higher, overexpression of both cFOS and TGF-β1 proteins in its metastatic nodal tissue extracts, when compared with the values of the two non-TNBC controls (with 'zero' disease-free interval and overall survival). This original observation suggests, for the first time, that both the cFOS and TGF-β1 may be considered as a pair of biomarkers for an early assessment of poor prognosis for TNBC patients. The possible clinical implication of this observation is discussed. |
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