| Title |
A prospective evaluation of changes in brain structure and cognitive functions in adult stem cell transplant recipients
|
|---|---|
| Published in |
Brain Imaging and Behavior, January 2013
|
| DOI | 10.1007/s11682-013-9221-8 |
| Pubmed ID | |
| Authors |
D. D. Correa, J. C. Root, R. Baser, D. Moore, K. K. Peck, E. Lis, T. B. Shore, H. T. Thaler, A. Jakubowski, N. Relkin |
| Abstract |
Hematopoietic stem cell transplantation (HSCT) is an efficacious treatment for many hematologic malignancies. However, the conditioning regimen of high-dose (HD) chemotherapy with or without total body irradiation (TBI) can be associated with neurotoxicity. In this prospective study, we used quantitative neuroimaging techniques to examine regional gray matter and ventricular volumes, and standardized neuropsychological tests to assess cognitive function before and 1 year after HSCT in 28 patients with hematologic malignancies and in ten healthy controls evaluated at similar intervals. Nineteen patients received conditioning treatment with HD chemotherapy alone and nine had both TBI and HD chemotherapy. There was a significant reduction in gray matter volume in the middle frontal gyrus bilaterally and in the left caudate nucleus in the patient group (all patients combined) but not among healthy controls over the 1-year follow-up period. There was a significant increase in left lateral ventricle volume and in total ventricle volume in the patient group, relative to healthy controls. Similar brain structural changes were seen for patients treated with HD chemotherapy alone. The neuropsychological results showed that 21% of patients could be classified as impaired at baseline. The Reliable Change Index suggested no significantly different rates of cognitive decline between patients and healthy controls. The findings suggest that HSCT patients may be at an increased risk for developing regional brain volume loss, and that subgroups may experience cognitive dysfunction prior to and 1 year following the transplant. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Russia | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 86 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 15% |
| Other | 12 | 13% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Master | 9 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Other | 17 | 19% |
| Unknown | 19 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 22 | 25% |
| Medicine and Dentistry | 15 | 17% |
| Neuroscience | 7 | 8% |
| Engineering | 5 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 25 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2022.
All research outputs
#4,079,326
of 23,072,295 outputs
Outputs from Brain Imaging and Behavior
#224
of 1,158 outputs
Outputs of similar age
#44,296
of 286,974 outputs
Outputs of similar age from Brain Imaging and Behavior
#1
of 11 outputs
Altmetric has tracked 23,072,295 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,158 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,974 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.