Chapter title |
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
|
---|---|
Chapter number | 339 |
Book title |
Natural Products in Cancer Prevention and Therapy
|
Published in |
Topics in current chemistry, July 2012
|
DOI | 10.1007/128_2012_339 |
Pubmed ID | |
Book ISBNs |
978-3-64-234574-6, 978-3-64-234575-3
|
Authors |
Kensler, Thomas W, Egner, Patricia A, Agyeman, Abena S, Visvanathan, Kala, Groopman, John D, Chen, Jian-Guo, Chen, Tao-Yang, Fahey, Jed W, Talalay, Paul, John M. Pezzuto, Nanjoo Suh, Thomas W. Kensler, Patricia A. Egner, Abena S. Agyeman, Kala Visvanathan, John D. Groopman, Jian-Guo Chen, Tao-Yang Chen, Jed W. Fahey, Paul Talalay, Kensler, Thomas W., Egner, Patricia A., Agyeman, Abena S., Groopman, John D., Fahey, Jed W., Thomas W Kensler, Patricia A Egner, John D Groopman, Jed W Fahey, Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P |
Editors |
John M. Pezzuto, Nanjoo Suh |
Abstract |
Sulforaphane is a promising agent under preclinical evaluation in many models of disease prevention. This bioactive phytochemical affects many molecular targets in cellular and animal models; however, amongst the most sensitive is Keap1, a key sensor for the adaptive stress response system regulated through the transcription factor Nrf2. Keap1 is a sulfhydryl-rich protein that represses Nrf2 signaling by facilitating the polyubiquitination of Nrf2, thereby enabling its subsequent proteasomal degradation. Interaction of sulforaphane with Keap1 disrupts this function and allows for nuclear accumulation of Nrf2 and activation of its transcriptional program. Enhanced transcription of Nrf2 target genes provokes a strong cytoprotective response that enhances resistance to carcinogenesis and other diseases mediated by exposures to electrophiles and oxidants. Clinical evaluation of sulforaphane has been largely conducted by utilizing preparations of broccoli or broccoli sprouts rich in either sulforaphane or its precursor form in plants, a stable β-thioglucose conjugate termed glucoraphanin. We have conducted a series of clinical trials in Qidong, China, a region where exposures to food- and air-borne carcinogens has been considerable, to evaluate the suitability of broccoli sprout beverages, rich in either glucoraphanin or sulforaphane or both, for their bioavailability, tolerability, and pharmacodynamic action in population-based interventions. Results from these clinical trials indicate that interventions with well characterized preparations of broccoli sprouts may enhance the detoxication of aflatoxins and air-borne toxins, which may in turn attenuate their associated health risks, including cancer, in exposed individuals. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 40% |
Unknown | 6 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 80% |
Practitioners (doctors, other healthcare professionals) | 2 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 1 | <1% |
United States | 1 | <1% |
Unknown | 113 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 17% |
Student > Master | 16 | 14% |
Student > Ph. D. Student | 15 | 13% |
Student > Bachelor | 13 | 11% |
Other | 4 | 3% |
Other | 12 | 10% |
Unknown | 35 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 15% |
Agricultural and Biological Sciences | 17 | 15% |
Medicine and Dentistry | 14 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
Immunology and Microbiology | 5 | 4% |
Other | 18 | 16% |
Unknown | 38 | 33% |