| Title |
RETRACTED ARTICLE: Oleandrin-Mediated Expression of Fas Potentiates Apoptosis in Tumor Cells
|
|---|---|
| Published in |
Journal of Clinical Immunology, June 2006
|
| DOI | 10.1007/s10875-006-9028-0 |
| Pubmed ID | |
| Authors |
YASHIN SREENIVASAN, PONGALI B. RAGHAVENDRA, SUNIL K. MANNA |
| Abstract |
Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin induces apoptosis, not necrosis in tumor cells but not in primary cells like peripheral blood mononuclear cells (PBMC) and neutrophils. Oleandrin inhibited NF-kappaB activation in tumor cells but not in primary cells. It induced cell death in NF-kappaB-overexpressed tumor cells. Oleandrin induced Fas expression thereby inducing apoptosis in tumor cells but not in primary cells. Dominant negative FADD inhibited oleandrin-induced cell death in tumor cells. Overall, these results suggest that oleandrin mediates apoptosis in tumor cells by inducing Fas but not in primary cells indicating its potential anti-cancer property with no or slight side effect. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 31% |
| Student > Master | 3 | 12% |
| Librarian | 2 | 8% |
| Other | 2 | 8% |
| Researcher | 2 | 8% |
| Other | 6 | 23% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 27% |
| Biochemistry, Genetics and Molecular Biology | 6 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Engineering | 2 | 8% |
| Medicine and Dentistry | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2013.
All research outputs
#3,257,747
of 22,699,621 outputs
Outputs from Journal of Clinical Immunology
#167
of 1,559 outputs
Outputs of similar age
#5,775
of 52,670 outputs
Outputs of similar age from Journal of Clinical Immunology
#4
of 7 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,559 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 52,670 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.