| Title |
Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2013
|
| DOI | 10.1007/s00018-013-1290-8 |
| Pubmed ID | |
| Authors |
Fábio G. Teixeira, Miguel M. Carvalho, Nuno Sousa, António J. Salgado |
| Abstract |
The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already demonstrated, both in vitro and in vivo, that MSCs are able to secrete a broad range of neuroregulatory factors that promote an increase in neurogenesis, inhibition of apoptosis and glial scar formation, immunomodulation, angiogenesis, neuronal and glial cell survival, as well as relevant neuroprotective actions on different pathophysiological contexts. Considering their protective action in lesioned sites, MSCs' secretome might also improve the integration of local progenitor cells in neuroregeneration processes, opening a door for their future use as therapeutical strategies in human clinical trials. Thus, in this review we analyze the current understanding of MSCs secretome as a new paradigm for the treatment of CNS neurodegenerative diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 340 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 2 | <1% |
| Greece | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 333 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 16% |
| Student > Master | 54 | 16% |
| Researcher | 45 | 13% |
| Student > Bachelor | 41 | 12% |
| Student > Doctoral Student | 21 | 6% |
| Other | 53 | 16% |
| Unknown | 72 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 20% |
| Biochemistry, Genetics and Molecular Biology | 63 | 19% |
| Medicine and Dentistry | 44 | 13% |
| Neuroscience | 22 | 6% |
| Engineering | 15 | 4% |
| Other | 43 | 13% |
| Unknown | 85 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2023.
All research outputs
#7,680,696
of 25,171,799 outputs
Outputs from Cellular and Molecular Life Sciences
#1,897
of 5,669 outputs
Outputs of similar age
#59,859
of 199,598 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 42 outputs
Altmetric has tracked 25,171,799 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,598 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.