Title |
Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non–Small-Cell Lung Cancer: Implications for Therapy
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Published in |
Journal of Thoracic Oncology, May 2013
|
DOI | 10.1097/jto.0b013e318287c3c5 |
Pubmed ID | |
Authors |
Martin K.H. Maus, Philip C. Mack, Stephanie H. Astrow, Craig L. Stephens, Gary D. Zeger, Peter P. Grimminger, Jack H. Hsiang, Eric Huang, Tianhong Li, Primo N. Lara, Kathleen D. Danenberg, David R. Gandara |
Abstract |
On the basis of the results of recent clinical trials, histology-based decision-making for therapy of non-small-cell lung cancer has been advocated. We hypothesized associations of the biomarkers excision repair cross-complementing 1 (ERCC1), ribonucleotide reductase M1 (RRM1), and thymidylate synthase (TS) with histology as a contributing factor to reported differences in chemotherapy outcomes between squamous cell carcinoma (SCCA) and adenocarcinoma (AC) subtypes. Here, we report analysis of the Response Genetics Inc., database and implications for histology-based therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 57% |
Romania | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 29% |
Student > Master | 3 | 21% |
Researcher | 2 | 14% |
Other | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 36% |
Nursing and Health Professions | 3 | 21% |
Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Social Sciences | 1 | 7% |
Chemistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 2 | 14% |