| Title |
Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation
|
|---|---|
| Published in |
Journal of Neuroimmune Pharmacology, March 2013
|
| DOI | 10.1007/s11481-013-9445-9 |
| Pubmed ID | |
| Authors |
Slava Rom, Yuri Persidsky |
| Abstract |
An accumulating body of evidence suggests that endocannabinoids and cannabinoid receptors type 1 and 2 (CB(1), CB(2)) play a significant role in physiologic and pathologic processes, including cognitive and immune functions. While the addictive properties of marijuana, an extract from the Cannabis plant, are well recognized, there is growing appreciation of the therapeutic potential of cannabinoids in multiple pathologic conditions involving chronic inflammation (inflammatory bowel disease, arthritis, autoimmune disorders, multiple sclerosis, HIV-1 infection, stroke, Alzheimer's disease to name a few), mainly mediated by CB(2) activation. Development of CB(2) agonists as therapeutic agents has been hampered by the complexity of their intracellular signaling, relative paucity of highly selective compounds and insufficient data regarding end effects in the target cells and organs. This review attempts to summarize recent advances in studies of CB(2) activation in the setting of neuroinflammation, immunomodulation and HIV-1 infection. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| United Kingdom | 2 | 13% |
| Netherlands | 1 | 6% |
| Colombia | 1 | 6% |
| Georgia | 1 | 6% |
| Canada | 1 | 6% |
| Unknown | 6 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 75% |
| Scientists | 2 | 13% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 332 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| Canada | 2 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Spain | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 321 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 47 | 14% |
| Student > Ph. D. Student | 45 | 14% |
| Student > Bachelor | 44 | 13% |
| Researcher | 41 | 12% |
| Student > Postgraduate | 20 | 6% |
| Other | 52 | 16% |
| Unknown | 83 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 16% |
| Agricultural and Biological Sciences | 33 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 33 | 10% |
| Psychology | 27 | 8% |
| Biochemistry, Genetics and Molecular Biology | 23 | 7% |
| Other | 69 | 21% |
| Unknown | 95 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2021.
All research outputs
#725,002
of 25,729,842 outputs
Outputs from Journal of Neuroimmune Pharmacology
#21
of 602 outputs
Outputs of similar age
#4,811
of 209,367 outputs
Outputs of similar age from Journal of Neuroimmune Pharmacology
#1
of 13 outputs
Altmetric has tracked 25,729,842 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 602 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.