| Title |
Reporting of Adherence in the VOICE Trial: Did Disclosure of Product Nonuse Increase at the Termination Visit?
|
|---|---|
| Published in |
AIDS and Behavior, February 2016
|
| DOI | 10.1007/s10461-016-1312-2 |
| Pubmed ID | |
| Authors |
Barbara S. Mensch, Elizabeth R. Brown, Karen Liu, Jeanne Marrazzo, Zvavahera Mike Chirenje, Kailazarid Gomez, Jeanna Piper, Karen Patterson, Ariane van der Straten |
| Abstract |
VOICE-a phase 2B, placebo-controlled, randomized trial testing daily use of an antiretroviral tablet (tenofovir or Truvada) or daily use of tenofovir gel in 5029 women from South Africa, Uganda, and Zimbabwe-found none of the drug regimens effective in reducing HIV-1 acquisition in the intent-to-treat analysis. More than half of women assigned to active products in a case cohort sample had no drug detected in any plasma specimens tested during the trial. Yet, in response to questions asked of participants during the trial, ≥90 % of doses were reportedly taken. To explore factors associated with low adherence, a behavioral termination visit questionnaire was developed after early closure of the oral tenofovir and vaginal gel arms. We hypothesized that participants would be more forthcoming about nonuse after they exited the trial than during monthly/quarterly follow-up visits. Comparison of adherence reporting at routine follow-up visits with reporting at trial termination, however, indicates that disclosure of product nonadherence did not increase at the termination visit as anticipated. In resource-limited settings where women value the ancillary benefits provided by trial participation and are concerned that disclosure of nonuse may jeopardize trial participation, objective measures of adherence may yield more meaningful data regarding the inability or reluctance to use than measures of product use derived from self-report. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 16% |
| Student > Master | 15 | 16% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Postgraduate | 5 | 5% |
| Student > Bachelor | 5 | 5% |
| Other | 17 | 18% |
| Unknown | 27 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 24% |
| Nursing and Health Professions | 13 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Social Sciences | 6 | 6% |
| Psychology | 5 | 5% |
| Other | 12 | 13% |
| Unknown | 30 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2017.
All research outputs
#14,405,036
of 23,849,058 outputs
Outputs from AIDS and Behavior
#2,022
of 3,566 outputs
Outputs of similar age
#151,441
of 301,012 outputs
Outputs of similar age from AIDS and Behavior
#50
of 98 outputs
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