Title |
Using Genetic Proxies for Lifecourse Sun Exposure to Assess the Causal Relationship of Sun Exposure with Circulating Vitamin D and Prostate Cancer Risk
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Published in |
Cancer Epidemiology, Biomarkers & Prevention, April 2013
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DOI | 10.1158/1055-9965.epi-12-1248 |
Pubmed ID | |
Authors |
Carolina Bonilla, Rebecca Gilbert, John P. Kemp, Nicholas J. Timpson, David M. Evans, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, William D. Fraser, Smith George Davey, Sarah J. Lewis, Mark Lathrop, Richard M. Martin |
Abstract |
Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis. Pigmentation traits influence sun exposure and therefore may affect prostate cancer risk. Because observational studies are vulnerable to confounding and measurement error, we used Mendelian randomization to examine the relationship of sun exposure with both prostate cancer risk and the intermediate phenotype, plasma levels of vitamin D. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Germany | 1 | <1% |
Argentina | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 130 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 20 | 15% |
Researcher | 15 | 11% |
Student > Bachelor | 15 | 11% |
Professor | 14 | 10% |
Student > Ph. D. Student | 12 | 9% |
Other | 29 | 21% |
Unknown | 31 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 24% |
Agricultural and Biological Sciences | 14 | 10% |
Computer Science | 11 | 8% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Nursing and Health Professions | 5 | 4% |
Other | 29 | 21% |
Unknown | 37 | 27% |