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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
|
|---|---|
| Published in |
Alzheimer's & Dementia: the Journal of the Alzheimer's Association, October 2016
|
| DOI | 10.1016/j.jalz.2016.09.002 |
| Pubmed ID | |
| Authors |
Jesse Mez, Jaeyoon Chung, Gyungah Jun, Joshua Kriegel, Alexandra P. Bourlas, Richard Sherva, Mark W. Logue, Lisa L. Barnes, David A. Bennett, Joseph D. Buxbaum, Goldie S. Byrd, Paul K. Crane, Nilüfer Ertekin-Taner, Denis Evans, M. Daniele Fallin, Tatiana Foroud, Alison Goate, Neill R. Graff-Radford, Kathleen S. Hall, M. Ilyas Kamboh, Walter A. Kukull, Eric B. Larson, Jennifer J. Manly, Alzheimer's Disease Genetics Consortium, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Kathryn L. Lunetta, Lindsay A. Farrer |
| Abstract |
African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power. We conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs. Two SNPs at novel loci, rs112404845 (P = 3.8 × 10(-8)), upstream of COBL, and rs16961023 (P = 4.6 × 10(-8)), downstream of SLC10A2, obtained genome-wide significant evidence of association with the posterior liability. An informed conditioning approach can detect LOAD genetic associations in AAs not identified by traditional GWAS. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 50% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 128 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 23% |
| Student > Bachelor | 14 | 11% |
| Student > Ph. D. Student | 13 | 10% |
| Student > Master | 13 | 10% |
| Other | 8 | 6% |
| Other | 24 | 19% |
| Unknown | 26 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 17% |
| Neuroscience | 19 | 15% |
| Medicine and Dentistry | 14 | 11% |
| Agricultural and Biological Sciences | 12 | 9% |
| Psychology | 9 | 7% |
| Other | 20 | 16% |
| Unknown | 32 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 66. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2018.
All research outputs
#648,424
of 25,374,917 outputs
Outputs from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#324
of 4,060 outputs
Outputs of similar age
#12,459
of 323,147 outputs
Outputs of similar age from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#2
of 37 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,147 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.