| Title |
Carbopol-Based Gels for Nasal Delivery of Progesterone
|
|---|---|
| Published in |
AAPS PharmSciTech, October 2008
|
| DOI | 10.1208/s12249-008-9144-7 |
| Pubmed ID | |
| Authors |
Grace Rathnam, N. Narayanan, R. Ilavarasan |
| Abstract |
The purpose of this study was to investigate the nasal absorption of progesterone from carbopol-based nasal gels in rabbits. Progesterone nasal gels were prepared by dispersing carbopol 974 (1%, 1.5%, and 2%) in distilled water followed by addition of progesterone/progesterone-beta cyclodextrin complex dissolved in propylene glycol then neutralization. The potential use of beta cyclodextrin (CD) as nasal absorption enhancer by simple addition, as a physical mixture and as a complex with progesterone was investigated. The absolute bioavailability of progesterone from nasal gels in rabbits was studied by estimating the serum progesterone level by competitive solid-phase enzyme immunoassay in comparison to intravenous injection. The carbopol gel formulations produced a significant increase in bioavailability. CD complex promotes the nasal absorption of progesterone from carbopol gels as compared with gels where the CD is added by simple addition and gels which do not contain CD. This method of addition of CD as an inclusion complex in the gels could be considered as a preferred platform in nasal drug administration. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 1 | 2% |
| Unknown | 48 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 22% |
| Researcher | 8 | 16% |
| Student > Postgraduate | 6 | 12% |
| Student > Doctoral Student | 4 | 8% |
| Student > Master | 4 | 8% |
| Other | 6 | 12% |
| Unknown | 10 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 20% |
| Medicine and Dentistry | 8 | 16% |
| Agricultural and Biological Sciences | 6 | 12% |
| Chemistry | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 13 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#3,257,747
of 22,701,287 outputs
Outputs from AAPS PharmSciTech
#98
of 1,466 outputs
Outputs of similar age
#10,417
of 90,136 outputs
Outputs of similar age from AAPS PharmSciTech
#1
of 9 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,466 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,136 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them