| Title |
Ageing of the human metaorganism: the microbial counterpart
|
|---|---|
| Published in |
GeroScience, February 2011
|
| DOI | 10.1007/s11357-011-9217-5 |
| Pubmed ID | |
| Authors |
Elena Biagi, Marco Candela, Susan Fairweather-Tait, Claudio Franceschi, Patrizia Brigidi |
| Abstract |
Human beings have been recently reviewed as 'metaorganisms' as a result of a close symbiotic relationship with the intestinal microbiota. This assumption imposes a more holistic view of the ageing process where dynamics of the interaction between environment, intestinal microbiota and host must be taken into consideration. Age-related physiological changes in the gastrointestinal tract, as well as modification in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbial ecosystem. Here we review the current knowledge of the changes occurring in the gut microbiota of old people, especially in the light of the most recent applications of the modern molecular characterisation techniques. The hypothetical involvement of the age-related gut microbiota unbalances in the inflamm-aging, and immunosenescence processes will also be discussed. Increasing evidence of the importance of the gut microbiota homeostasis for the host health has led to the consideration of medical/nutritional applications of this knowledge through the development of probiotic and prebiotic preparations specific for the aged population. The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 488 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 3 | <1% |
| Netherlands | 2 | <1% |
| Portugal | 2 | <1% |
| France | 2 | <1% |
| Brazil | 2 | <1% |
| Italy | 2 | <1% |
| Switzerland | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 465 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 92 | 19% |
| Student > Ph. D. Student | 79 | 16% |
| Student > Master | 63 | 13% |
| Student > Bachelor | 59 | 12% |
| Student > Doctoral Student | 27 | 6% |
| Other | 73 | 15% |
| Unknown | 95 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 140 | 29% |
| Medicine and Dentistry | 74 | 15% |
| Biochemistry, Genetics and Molecular Biology | 64 | 13% |
| Immunology and Microbiology | 27 | 6% |
| Nursing and Health Professions | 16 | 3% |
| Other | 55 | 11% |
| Unknown | 112 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2023.
All research outputs
#1,978,746
of 25,998,826 outputs
Outputs from GeroScience
#246
of 1,655 outputs
Outputs of similar age
#8,019
of 122,748 outputs
Outputs of similar age from GeroScience
#2
of 17 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,748 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.