| Title |
The role of optical coherence tomography in Alzheimer’s disease
|
|---|---|
| Published in |
International Journal of Retina and Vitreous , October 2016
|
| DOI | 10.1186/s40942-016-0049-4 |
| Pubmed ID | |
| Authors |
Leonardo Provetti Cunha, Ana Laura Maciel Almeida, Luciana Virgínia Ferreira Costa-Cunha, Carolina Ferreira Costa, Mário L. R. Monteiro |
| Abstract |
Alzheimer's disease (AD) is the most common cause of dementia and its incidence is increasing worldwide along with population aging. Previous clinical and histologic studies suggest that the neurodegenerative process, which affects the brain, may also affect the retina of AD patients. Optical coherence tomography (OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Several previous studies demonstrated that both peripapillary retinal nerve fiber layer and macular thickness measurements assessed by OCT were able to detect neuronal loss in AD. Moreover, recent advances in OCT technology, have allowed substantial enhancement in ultrastructural evaluation of the macula, enabling the assessment not only of full-thickness retinal measurements but also of inner retinal layers, which seems to be a promising approach, mainly regarding the assessment of retinal ganglion cell layer impairment in AD patients. Furthermore, retinal neuronal loss seems to correlate with cognitive impairment in AD, reinforcing the promising role of OCT in the clinical evaluation of these patients. The purpose of this article is to review the main findings on OCT in AD patients, to discuss the role of this important diagnostic tool in these patients and how OCT technology may be useful in understanding morphological retinal changes in AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 18% |
| Student > Ph. D. Student | 12 | 12% |
| Student > Bachelor | 11 | 11% |
| Other | 9 | 9% |
| Student > Doctoral Student | 8 | 8% |
| Other | 17 | 17% |
| Unknown | 23 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 28% |
| Neuroscience | 11 | 11% |
| Engineering | 10 | 10% |
| Psychology | 7 | 7% |
| Computer Science | 6 | 6% |
| Other | 15 | 15% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2023.
All research outputs
#2,480,109
of 25,604,262 outputs
Outputs from International Journal of Retina and Vitreous
#11
of 266 outputs
Outputs of similar age
#41,125
of 323,621 outputs
Outputs of similar age from International Journal of Retina and Vitreous
#2
of 3 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 266 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,621 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.