| Title |
Neural Stem-Like Cells Derived from Human Amnion Tissue are Effective in Treating Traumatic Brain Injury in Rat
|
|---|---|
| Published in |
Neurochemical Research, March 2013
|
| DOI | 10.1007/s11064-013-1012-5 |
| Pubmed ID | |
| Authors |
Zhong-Jie Yan, Peng Zhang, Yu-Qin Hu, Hong-Tian Zhang, Sun-Quan Hong, Hong-Long Zhou, Mao-Ying Zhang, Ru-Xiang Xu |
| Abstract |
Although human amnion derived mesenchymal stem cells (AMSC) are a promising source of stem cells, their therapeutic potential for traumatic brain injury (TBI) has not been widely investigated. In this study, we evaluated the therapeutic potential of AMSC using a rat TBI model. AMSC were isolated from human amniotic membrane and characterized by flow cytometry. After induction, AMSC differentiated in vitro into neural stem-like cells (AM-NSC) that expressed higher levels of the neural stem cell markers, nestin, sox2 and musashi, in comparison to undifferentiated AMSC. Interestingly, the neurotrophic factors, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin 3 (NT-3), glial cell derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) were markedly upregulated after neural stem cell induction. Following transplantation in a rat TBI model, significant improvements in neurological function, brain tissue morphology, and higher levels of BDNF, NGF, NT-3, GDNF and CNTF, were observed in the AM-NSC group compared with the AMSC and Matrigel groups. However, few grafted cells survived with minimal differentiation into neural-like cells. Together, our results suggest that transplantation of AM-NSC promotes functional rehabilitation of rats with TBI, with enhanced expression of neurotrophic factors a likely mechanistic pathway. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 55 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Researcher | 10 | 18% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Professor | 5 | 9% |
| Other | 12 | 21% |
| Unknown | 5 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 25% |
| Medicine and Dentistry | 11 | 19% |
| Neuroscience | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Computer Science | 1 | 2% |
| Other | 7 | 12% |
| Unknown | 10 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2013.
All research outputs
#14,747,687
of 22,701,287 outputs
Outputs from Neurochemical Research
#1,221
of 2,088 outputs
Outputs of similar age
#118,089
of 195,434 outputs
Outputs of similar age from Neurochemical Research
#13
of 27 outputs
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