| Title |
Cognitive fatigue is associated with reduced anterior internal capsule integrity in veterans with history of mild to moderate traumatic brain injury
|
|---|---|
| Published in |
Brain Imaging and Behavior, October 2016
|
| DOI | 10.1007/s11682-016-9594-6 |
| Pubmed ID | |
| Authors |
Alexandra L. Clark, Lisa Delano-Wood, Scott F. Sorg, Madeleine L. Werhane, Karen L. Hanson, Dawn M. Schiehser |
| Abstract |
No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Controls [VCs] = 25]) with and without history of mmTBI underwent structural 3T DTI scans and completed questionnaires related to cognitive fatigue and psychiatric symptoms. Tractography was employed on six regions of interest, including the anterior and posterior limbs of the internal capsule; genu; body and splenium of the corpus callosum; and cingulum bundle. Group analyses revealed that those with history of mmTBI displayed significantly greater levels of cognitive fatigue relative to those with no history of head injury (p = .02). Within the mmTBI group, independent of psychiatric symptoms, decreased white matter microstructural integrity of the left anterior internal capsule was associated with greater levels of cognitive fatigue (p = .01). Results show that the subjective experience of cognitive fatigue following neurotrauma may be linked to the disruption of striato-thalamo-cortical tracts that are important in mediating arousal and higher-order cognitive processes. These findings build upon those from existing functional neuroimaging studies in those with history of TBI, providing further evidence for the neural basis of cognitive fatigue in head injured adults. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 7 | 15% |
| Student > Bachelor | 6 | 13% |
| Student > Master | 6 | 13% |
| Researcher | 5 | 11% |
| Student > Ph. D. Student | 5 | 11% |
| Other | 8 | 17% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 20% |
| Psychology | 7 | 15% |
| Nursing and Health Professions | 6 | 13% |
| Agricultural and Biological Sciences | 4 | 9% |
| Neuroscience | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 14 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2016.
All research outputs
#18,478,448
of 22,896,955 outputs
Outputs from Brain Imaging and Behavior
#862
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Outputs of similar age
#242,082
of 319,910 outputs
Outputs of similar age from Brain Imaging and Behavior
#41
of 57 outputs
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