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Long-Term Outcome of Kidney Transplantation in Recipients with Focal Segmental Glomerulosclerosis

Overview of attention for article published in Clinical Journal of The American Society of Nephrology, October 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)

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Title
Long-Term Outcome of Kidney Transplantation in Recipients with Focal Segmental Glomerulosclerosis
Published in
Clinical Journal of The American Society of Nephrology, October 2016
DOI 10.2215/cjn.03060316
Pubmed ID
Authors

Anna Francis, Peter Trnka, Steven J McTaggart

Abstract

FSGS can recur after kidney transplantation and is associated with poor graft outcomes. We aimed to assess the incidence of FSGS recurrence post-transplant and determine the effect of graft source on recurrence and graft survival in patients with biopsy-proven FSGS. Using the Australian and New Zealand Dialysis and Transplant Registry, we assessed incidence of FSGS, the influence of donor type on the risk of FSGS recurrence, and graft loss in recipients with ESRD caused by primary FSGS using Kaplan-Meier and logistic regression analyses. Between 1992 and 2011, 736 first kidney transplants were performed in 666 adults and 70 children (≤20 years old) with biopsy-proven primary FSGS. FSGS recurred in 76 (10.3%) patients. Younger age (P<0.001), nonwhite ethnicity (P=0.02), and having a live donor (P=0.02) were independent risk factors associated with recurrence. Median graft survival was significantly better for live donor compared with deceased donor grafts (14.8 versus 12.1 years; P<0.01). Disease recurrence predicted poor graft outcomes, with 52% (95% confidence interval, 40% to 63%) 5-year graft survival in the recurrence group compared with 83% (95% confidence interval, 79% to 86%) in the group without recurrent disease (P<0.001). FSGS recurrence after kidney transplantation was more common in live donor kidneys. Despite this, graft survival in live donor recipients was significantly better for both children and adults with FSGS. We propose that live donor transplantation should not be avoided in patients with FSGS.

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X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Australia 1 1%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 10 13%
Professor 8 10%
Researcher 7 9%
Student > Bachelor 6 8%
Student > Master 6 8%
Other 18 23%
Unknown 22 29%
Readers by discipline Count As %
Medicine and Dentistry 42 55%
Agricultural and Biological Sciences 4 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Computer Science 1 1%
Immunology and Microbiology 1 1%
Other 4 5%
Unknown 23 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2019.
All research outputs
#7,150,392
of 25,377,790 outputs
Outputs from Clinical Journal of The American Society of Nephrology
#2,668
of 4,057 outputs
Outputs of similar age
#100,631
of 322,987 outputs
Outputs of similar age from Clinical Journal of The American Society of Nephrology
#50
of 68 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,057 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.